Objective: To investigate the role of the acute glucagon response in the long-term remission of newly diagnosed type 2 diabetes mellitus following short-term intensive insulin therapy (IIT). Methods: Ten patients with newly diagnosed type 2 diabetes mellitus received IIT. Intravenous glucose tolerance tests and the clamp technique were performed pre- and post-IIT. Remission was defined as maintenance of target glycaemic control without anti-diabetic agents for 1 year. Results: The remission rate was 50% (5/10). There were no differences in the acute insulin response or glucose infusion rate between groups. The acute glucagon response (AGR) in the remission group pre-IIT was significantly higher than that in the non-remission group (mean 163.02 pg/mL/min vs. mean 16.29 pg/mL/min). The mean AGR post-IIT was lower in the remission group than that in the non-remission group (0 pg/mL/min vs. 19.91 pg/mL/min). Spearman analysis indicated that the AGR pre-IIT and the change in the AGR were correlated with remission (r = 0.731). Conclusion: The insulin-mediated glucose disposal rate was significantly improved with the normalization of blood glucose levels following transient IIT. Subjects with a higher AGR pre-IIT and a greater AGR decrease post-IIT displayed a greater likelihood of long-term remission.
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外文
被引次数：
WOS：
中科院(CAS)分区：
出版当年[2015]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
最新[2025]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
JCR分区：
出版当年[2014]版：
Q3MEDICINE, RESEARCH & EXPERIMENTALQ3PHARMACOLOGY & PHARMACY
最新[2023]版：
Q4MEDICINE, RESEARCH & EXPERIMENTALQ4PHARMACOLOGY & PHARMACY
第一作者单位：[1]Department of Endocrinology, China-Japan Friendship Hospital, Beijing, China[*1]Department of Endocrinology, China-Japan Friendship Hospital, No. 2 Yinghua Eastern Street, Beijing,China
通讯作者：
通讯机构：[1]Department of Endocrinology, China-Japan Friendship Hospital, Beijing, China[*1]Department of Endocrinology, China-Japan Friendship Hospital, No. 2 Yinghua Eastern Street, Beijing,China
推荐引用方式(GB/T 7714)：
Zhang Bo,Chen Yan-yan,Yang Zhao-jun,et al.Improvement in insulin sensitivity following intensive insulin therapy and association of glucagon with long-term diabetes remission[J].JOURNAL of INTERNATIONAL MEDICAL RESEARCH.2016,44(6):1543-1550.doi:10.1177/0300060516668433.
APA：
Zhang, Bo,Chen, Yan-yan,Yang, Zhao-jun,Wang, Xin&Li, Guang-wei.(2016).Improvement in insulin sensitivity following intensive insulin therapy and association of glucagon with long-term diabetes remission.JOURNAL of INTERNATIONAL MEDICAL RESEARCH,44,(6)
MLA：
Zhang, Bo,et al."Improvement in insulin sensitivity following intensive insulin therapy and association of glucagon with long-term diabetes remission".JOURNAL of INTERNATIONAL MEDICAL RESEARCH 44..6(2016):1543-1550
