Cronkhite-Canada syndrome (CCS) is a very rare disease which may cause malignant transformation. A combination regimen including corticosteroids are common therapy for CCS, however the decrease of medicine may lead to CCS relapse and also may contribute to malignant transformation of the polyps in gastrointestinal tract. We retrospectively analyze one case of recurrent CCS from the first time of treatment after resection of colon cancer and readjust the usage of corticoids, the patient recovered well. The nine months follow-up showed non gastrointestinal tumor occurred or relapsed. We believe close follow-up should be taken when CCS patients are making medicine dosage alteration and tumor marker such as CEA may be included in the surveillance examination. When improvement using conservative treatment can be neither obtained nor is expected, the use of surgery should be considered.