Preclinical pharmacokinetic evaluation and metabolites identification of methyl salicylate-2-O-beta-D-lactoside in rats using LC-MS/MS and Q-TOF-MS methods
单位：[1]Peking Union Med Coll, Inst Mat Med, Beijing 100050, Peoples R China[2]Chinese Acad Med Sci, Beijing 100050, Peoples R China[3]China Japan Friendship Hosp, Dept Pharm, Beijing 100029, Peoples R China[4]Binzhou Med Univ, Yantai 256603, Peoples R China[5]China Japan Friendship Hosp, Inst Clin Med Sci, Dept Pharmacol, Beijing 100029, Peoples R China
Methyl salicylate-2-O-beta-D-lactoside (MSL) is a natural salicylate derivative from the traditional Chinese medicine of Gaultheria yunnanensis (Franch.) Rehder (G. yunnanensis). As a non-steroidal anti-inflammatory drug (NSAID), MSL exerts a significant anti-arthritis effect but hardly has any gastrointestinal toxicity. In this paper, the pharmacokinetics, distribution, excretion and identification of MSL and its metabolites are described following rat oral and intravenous administration. The biological samples were quantified by UPLC-MS/MS and the metabolites in urine and feces were identified by using Q-TOF-MS. These results will support future investigations leading to clinical development of this drug. (C) 2015 Elsevier B.V. All rights reserved.
基金：
National Natural Science FoundationNational Natural Science Foundation of China (NSFC) [81073120, 81373388]; Beijing Municipal Scientific and Technological Program of China [Z131100002713002]
第一作者单位：[1]Peking Union Med Coll, Inst Mat Med, Beijing 100050, Peoples R China[2]Chinese Acad Med Sci, Beijing 100050, Peoples R China[3]China Japan Friendship Hosp, Dept Pharm, Beijing 100029, Peoples R China
通讯作者：
通讯机构：[1]Peking Union Med Coll, Inst Mat Med, Beijing 100050, Peoples R China[2]Chinese Acad Med Sci, Beijing 100050, Peoples R China[*1]Chinese Acad Med Sci, Inst Mat Med, 1 Xian Nong Tan St, Beijing 100050, Peoples R China
推荐引用方式(GB/T 7714)：
Zhang Dan,Huang Chao,Xin Wenyu,et al.Preclinical pharmacokinetic evaluation and metabolites identification of methyl salicylate-2-O-beta-D-lactoside in rats using LC-MS/MS and Q-TOF-MS methods[J].JOURNAL of PHARMACEUTICAL and BIOMEDICAL ANALYSIS.2015,109:1-10.doi:10.1016/j.jpba.2015.02.022.
APA：
Zhang, Dan,Huang, Chao,Xin, Wenyu,Ma, Xiaowei,Zhang, Weiku...&Du, Guanhua.(2015).Preclinical pharmacokinetic evaluation and metabolites identification of methyl salicylate-2-O-beta-D-lactoside in rats using LC-MS/MS and Q-TOF-MS methods.JOURNAL of PHARMACEUTICAL and BIOMEDICAL ANALYSIS,109,
MLA：
Zhang, Dan,et al."Preclinical pharmacokinetic evaluation and metabolites identification of methyl salicylate-2-O-beta-D-lactoside in rats using LC-MS/MS and Q-TOF-MS methods".JOURNAL of PHARMACEUTICAL and BIOMEDICAL ANALYSIS 109.(2015):1-10
