单位：[1]Heidelberg Univ, Med Fac Mannheim, Dept Med 2, Sect Mol Hepatol, D-68167 Mannheim, Germany[2]Saarland Univ Hosp, Dept Med 2, Homburg, Germany[3]Shanghai Jiao Tong Univ, Sch Med, Ren Ji Hosp, Dept Gastroenterol, Shanghai 200030, Peoples R China[4]Beijing China Japan Friendship Hosp, Dept Pathol, Beijing, Peoples R China
Massive hepatic necrosis is a key event underlying acute liver failure, a serious clinical syndrome with high mortality. Massive hepatic necrosis in acute liver failure has unique pathophysiological characteristics including extremely rapid parenchymal cell death and removal. On the other hand, massive necrosis rapidly induces the activation of liver progenitor cells, the so-called "second pathway of liver regeneration." The final clinical outcome of acute liver failure depends on whether liver progenitor cell-mediated regeneration can efficiently restore parenchymal mass and function within a short time. This review summarizes the current knowledge regarding massive hepatic necrosis and liver progenitor cell-mediated regeneration in patients with acute liver failure, the two sides of one coin.
基金：
Returned Overseas Chinese ScholarsScientific Research Foundation for the Returned Overseas Chinese Scholars; State Education Ministry (Starting Research Foundation for Returned Overseas Chinese Scholars) [J20050337491010-G50523]; People's Republic of China; Else-Kroner Fresenius; Chinese Nature Science Foundation [30770962, 30971333, 81170421, 81470869]; Chinese High Technology "863"programme [2006AA02A411]; BMBF "Virtual liver" and "cell therapy"Federal Ministry of Education & Research (BMBF) [01GN0987]; Deutsche ForschungsgemeinschaftGerman Research Foundation (DFG) [DO373/6-1, DO 373/8-1, TRR-SFB 77]; IT-Liver ITN training grant
第一作者单位：[1]Heidelberg Univ, Med Fac Mannheim, Dept Med 2, Sect Mol Hepatol, D-68167 Mannheim, Germany[*1]Heidelberg Univ, Med Fac Mannheim, Dept Med 2, Sect Mol Hepatol, Theodor Kutzer Ufer 1-3, D-68167 Mannheim, Germany
通讯作者：
通讯机构：[1]Heidelberg Univ, Med Fac Mannheim, Dept Med 2, Sect Mol Hepatol, D-68167 Mannheim, Germany[*1]Heidelberg Univ, Med Fac Mannheim, Dept Med 2, Sect Mol Hepatol, Theodor Kutzer Ufer 1-3, D-68167 Mannheim, Germany
推荐引用方式(GB/T 7714)：
Weng Hong-Lei,Cai Xiaobo,Yuan Xiaodong,et al.Two sides of one coin: massive hepatic necrosis and progenitor cell-mediated regeneration in acute liver failure[J].FRONTIERS in PHYSIOLOGY.2015,6:doi:10.3389/fphys.2015.00178.
APA：
Weng, Hong-Lei,Cai, Xiaobo,Yuan, Xiaodong,Liebe, Roman,Dooley, Steven...&Wang, Tai-Ling.(2015).Two sides of one coin: massive hepatic necrosis and progenitor cell-mediated regeneration in acute liver failure.FRONTIERS in PHYSIOLOGY,6,
MLA：
Weng, Hong-Lei,et al."Two sides of one coin: massive hepatic necrosis and progenitor cell-mediated regeneration in acute liver failure".FRONTIERS in PHYSIOLOGY 6.(2015)
