The aim of this trial was to evaluate the efficacy and safety of intra-articular administration of tranexamic acid (TXA) plus diluted-epinephrine (DEP) on perioperative blood loss and transfusion in primary unilateral total knee arthroplasty (TKA) without drainage. One hundred patients scheduled to undergo TKA were randomized into two groups: 50 patients received intra-articular 3 g TXA plus 0.25 mg DEP (1:200,000), and 50 patients received 3 g topical TXA alone. The results showed that topical combined administration significantly reduced total blood loss (P = 0.006), hidden blood loss (P = 0.000) and transfusion rate (0% vs. 4%), without increasing the risk of thromboembolic and hemodynamic complications (P > 0.05). Therefore, topical TXA plus DEP was effective and safe in reducing blood loss and transfusion following TKA, without substantial complications. (C) 2015 Elsevier Inc. All rights reserved.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81372013]; Research Fund of China-Japan Friendship Hospital [2013-MS-27]; China-Japan Friendship Hospital Youth Science and Technology Excellence Project [2014-QNYC-A-06]
通讯机构：[*1]China Japan Friendship Hosp, Dept Orthoped Surg, Beijing 100029, Peoples R China
推荐引用方式(GB/T 7714)：
Gao Fuqiang,Sun Wei,Guo Wanshou,et al.Topical Administration of Tranexamic Acid Plus Diluted-Epinephrine in Primary Total Knee Arthroplasty: A Randomized Double-Blinded Controlled Trial[J].JOURNAL of ARTHROPLASTY.2015,30(8):1354-1358.doi:10.1016/j.arth.2015.03.003.
APA：
Gao, Fuqiang,Sun, Wei,Guo, Wanshou,Li, Zirong,Wang, Weiguo&Cheng, Liming.(2015).Topical Administration of Tranexamic Acid Plus Diluted-Epinephrine in Primary Total Knee Arthroplasty: A Randomized Double-Blinded Controlled Trial.JOURNAL of ARTHROPLASTY,30,(8)
MLA：
Gao, Fuqiang,et al."Topical Administration of Tranexamic Acid Plus Diluted-Epinephrine in Primary Total Knee Arthroplasty: A Randomized Double-Blinded Controlled Trial".JOURNAL of ARTHROPLASTY 30..8(2015):1354-1358
医学