单位：[1]Department of Epidemiology, Tulane School of Public Health and Tropical Medicine, New Orleans, LA[2]China-Japan Friendship Hospital, Beijing, China[3]Peking University Peoples' Hospital, Beijing, China[4]Sun Yat-sen University Third Hospital, Guangzhou, China中山大学附属第三医院[5]Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China[6]Chinese PLA General Hospital, Beijing, China[7]Xiangya Second Hospital, Hunan, China[8]Peking University First Hospital, Beijing, China[9]Shanxi Province People's Hospital, Shanxi, China[10]The First Affiliated Hospital, Chinese Medical University, Liaoning, China[11]The Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu, China[12]Qilu Hospital, Qilu Hospital of Shandong University, Shandong, China[13]Henan Province People's Hospital, Henan, China[14]West China Hospital, Sichuan University, Sichuan, China四川大学华西医院[15]Xijing Hospital, Fourth Military Medical University, Shaanxi, China[16]Xinjiang Uygur Autonomous Region's Hospital, Xinjiang, China[17]The Second Affiliated Hospital of Harbin Medical University, Heilongjiang, China[18]Fujian Provincial Hospital, Fujian, China
Aims: To examine the associations of BMI and waist circumference with glucose metabolism and (pre) diabetes among adults with BMI < 25 kg/m(2). Methods: We conducted a cross-sectional study in a nationally representative sample (10,098 men and 17,454 women) of Chinese adults aged >= 20 years with BMI < 25 kg/m(2). Glucose levels after at least 10 hours of overnight fasting, at 30 minutes and at 120 minutes after a standard 75-g oral glucose load were measured. Associations of BMI and waist circumference with outcomes were examined by general linear models for continuous outcomes and by logistic regression models for dichotomous outcomes. Results: Among those with BMI < 25 kg/m(2), 18.8% of men and 17.1% of women had abnormal glucose metabolism, including 4.9% of men and 3.8% of women with undiagnosed type 2 diabetes. For each SD increase in BMI (2.1 kg/m(2)) and waist circumference (8.3 cm), fasting glucose levels increased by 0.128 and 0.170 mmol/L in men, and by 0.112 and 0.167 mmol/L in women, respectively; the corresponding increases for 2-hour post-load glucose levels were 0.121 and 0.217 mmol/L in men, and 0.241 and 0.362 mmol/L in women. When simultaneously included in the same model, these associations with waist circumference were stronger than with BMI. Conclusion: Obesity measures are associated with abnormal glucose metabolism and diabetes, with central obesity playing a more prominent role than general obesity in Chinese population with BMI < 25 kg/m(2). Chinese diabetes prevention and treatment programs should incorporate targeting of normal weight adults with central obesity.
基金：
Chinese Medical Association Foundation; Chinese Diabetes Society; EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENTUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) [K12HD043451] Funding Source: NIH RePORTER
Li Shengxu,Xiao Jianzhong,Ji Linong,et al.BMI and waist circumference are associated with impaired glucose metabolism and type 2 diabetes in normal weight Chinese adults[J].JOURNAL of DIABETES and ITS COMPLICATIONS.2014,28(4):470-476.doi:10.1016/j.jdiacomp.2014.03.015.
APA：
Li, Shengxu,Xiao, Jianzhong,Ji, Linong,Weng, Jianping,Jia, Weiping...&Yang, Wenying.(2014).BMI and waist circumference are associated with impaired glucose metabolism and type 2 diabetes in normal weight Chinese adults.JOURNAL of DIABETES and ITS COMPLICATIONS,28,(4)
MLA：
Li, Shengxu,et al."BMI and waist circumference are associated with impaired glucose metabolism and type 2 diabetes in normal weight Chinese adults".JOURNAL of DIABETES and ITS COMPLICATIONS 28..4(2014):470-476
