A genome-wide association study in the Chinese Han population has identified several novel genetic variants of the serine racemase (SRR) gene in type 2 diabetes. Our purpose was to systematically evaluate the contribution of SRR variants in the Chinese Han population. rs391300 and rs4523957 in SRR were genotyped respectively in the two independent populations. A meta-analysis was used to estimate the effects of SRR in 21,305 Chinese Han individuals. Associations between single-nucleotide polymorphisms and diabetes-related phenotypes were analyzed among 2,615 newly diagnosed type 2 diabetes patients and 5,029 controls. Neither rs391300 nor rs4523957 were associated with type 2 diabetes in populations. Furthermore, meta-analysis did not confirm an association between type 2 diabetes and SRR. In the controls, rs391300-A and rs4523957-G were associated with higher 30-min plasma glucose in an oral glucose tolerance test. The present study did not confirm that SRR was associated with type 2 diabetes.
基金：
China Medical Association Research Fund; National High-technology Research and Development Program of China (863 Program) [2012AA02A509]; National Key Basic Research Program of China (973 Program)National Basic Research Program of China [2011CB504000]
第一作者单位：[1]Peking Univ, Peoples Hosp, Ctr Diabet, Dept Endocrinol & Metab, Beijing 100871, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Zhang Simin,Xiao Jianzhong,Ren Qian,et al.Association of serine racemase gene variants with type 2 diabetes in the Chinese Han population[J].JOURNAL of DIABETES INVESTIGATION.2014,5(3):286-289.doi:10.1111/jdi.12145.
APA：
Zhang, Simin,Xiao, Jianzhong,Ren, Qian,Han, Xueyao,Tang, Yong...&Ji, Linong.(2014).Association of serine racemase gene variants with type 2 diabetes in the Chinese Han population.JOURNAL of DIABETES INVESTIGATION,5,(3)
MLA：
Zhang, Simin,et al."Association of serine racemase gene variants with type 2 diabetes in the Chinese Han population".JOURNAL of DIABETES INVESTIGATION 5..3(2014):286-289
