单位：[1]Department of Cell Biology, National Research Institute of Family Planning, Beijing 100081, China[2]Department of Neurology in Medical Healthcare Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China临床科室神经内科神经内科首都医科大学附属北京友谊医院[3]Department of Anatomy, Capital Medical University, Beijing 100069, China[4]WHO Collaborating Center for Research in Human Reproduction, National Research Institute of Family Planning, Beijing 100081, China
Tanshinol (3-(3',4'-dihydroxyphenyl)-(2R)-lactic acid, TSL) is widely used in traditional Chinese medicine for the treatment of cardiovascular and cerebrovascular diseases. Here, we assessed whether TSL protected hippocampus and attenuated vascular dementia (VD) development in rats. The behavioral analysis showed that TSL could decrease the distance and latency time, and increase the swim speed in water maze in rats subjected to VD. TSL remarkably increased acetylcholine level and decreased acetylcholinesterase activity in rats subjected to VD. Likewise, TSL remarkably decreased malondialdehyde and increased superoxide dismutase levels in rats subjected to VD. Furthermore, treatment with TSL reduced the level of dead neurons in dentate gyrus. In addition, TSL upregulated growth-associated protein 43 (GAP43) and vascular endothelial growth factor (VEGF) expression and downregulated phosphorylated Akt (p-AKt) and phosphorylated glycogen synthase kinase (p-GSK3β) expression in hippocampus in rats subjected to VD. These results suggest that TSL may be a potential compound in VD model.
基金：
National Key Grant of Basic Research Project
(2010CB530403) and Capital Medical University Key Laboratory Project (2013NZDJ01).
第一作者单位：[1]Department of Cell Biology, National Research Institute of Family Planning, Beijing 100081, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Shi Cui-Ge,Yang Yi-Shu,Li Hui,et al.Tanshinol protects hippocampus and attenuates vascular dementia development[J].JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH.2014,16(6):667-76.doi:10.1080/10286020.2014.930131.
APA：
Shi Cui-Ge,Yang Yi-Shu,Li Hui,Zhang Ying,Wang Ning...&Zhang Shu-Cheng.(2014).Tanshinol protects hippocampus and attenuates vascular dementia development.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,16,(6)
MLA：
Shi Cui-Ge,et al."Tanshinol protects hippocampus and attenuates vascular dementia development".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 16..6(2014):667-76
