单位：[1]Beijing Union Med Coll Hosp, Peking Union Med Coll, Dept Rheumatol, Beijing 100730, Peoples R China[2]Chinese Acad Med Sci, Beijing 100730, Peoples R China[3]China Japan Friendship Hosp, Dept Hlth Care, Beijing 100029, Peoples R China[4]Beijing Union Med Coll Hosp, Peking Union Med Coll, Dept Orthopaed, Beijing 100730, Peoples R China
We present a case of hypertrophic osteoarthropathy (PHO), with painful synovium hyperplasia involving both knees that was refractory to corticosteroid treatment. His rheumatoid factor and anti-CCP antibody was negative, and his serum ESR and CRP level was within normal range. Histological examination of the synovium obtained from his right knee revealed endothelial hyperplasia and vascular thickening without inflammation that was in association with aberrant expression of CD200/CD200R1, which highlighted the importance of aberrant CD200/CD200R1 in the regulation of the endothelial activation that contributed to the development of synovium hyperplasia in this PHO patient.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30400410, 30972731, 81172859, 81273312]; National High Technology Research and Development Project of China (973 Project)National Basic Research Program of ChinaNational High Technology Research and Development Program of China [2007CB512405]
第一作者单位：[1]Beijing Union Med Coll Hosp, Peking Union Med Coll, Dept Rheumatol, Beijing 100730, Peoples R China[2]Chinese Acad Med Sci, Beijing 100730, Peoples R China[3]China Japan Friendship Hosp, Dept Hlth Care, Beijing 100029, Peoples R China
通讯作者：
通讯机构：[1]Beijing Union Med Coll Hosp, Peking Union Med Coll, Dept Rheumatol, Beijing 100730, Peoples R China[2]Chinese Acad Med Sci, Beijing 100730, Peoples R China
推荐引用方式(GB/T 7714)：
Ren Yan,Leng Xiao-mei,Yang Bo,et al.Aberrant CD200/CD200R1 expression contributes to painful synovium hyperplasia in a patient with primary hypertrophic osteoarthropathy[J].RHEUMATOLOGY INTERNATIONAL.2013,33(10):2509-2512.doi:10.1007/s00296-013-2732-1.
APA：
Ren, Yan,Leng, Xiao-mei,Yang, Bo&Zhang, Xuan.(2013).Aberrant CD200/CD200R1 expression contributes to painful synovium hyperplasia in a patient with primary hypertrophic osteoarthropathy.RHEUMATOLOGY INTERNATIONAL,33,(10)
MLA：
Ren, Yan,et al."Aberrant CD200/CD200R1 expression contributes to painful synovium hyperplasia in a patient with primary hypertrophic osteoarthropathy".RHEUMATOLOGY INTERNATIONAL 33..10(2013):2509-2512
