单位：[1]China Japan Friendship Hosp, Minist Hlth, Dept Gastroenterol, Beijing 100029, Peoples R China[2]China Japan Friendship Hosp, Minist Hlth, Dept Nucl Med, Beijing 100029, Peoples R China[3]Peking Union Med Coll, Grad Sch, Beijing 100021, Peoples R China[4]Chinese Acad Med Sci, Beijing 100730, Peoples R China
OBJECTIVE: Functional dyspepsia is a heterogeneous disorder and different pathophysiological mechanisms underlie its symptom patterns. This study investigated the relationship between dyspepsia symptoms and overall and proximal gastric emptying in patients with functional dyspepsia. METHODS: A total of 93 patients with functional dyspepsia and 32 healthy subjects were enrolled in this cross-sectional study. Prevalence and severity of eight dyspepsia symptoms were recorded. Gastric emptying was measured using single photon emission computed tomography scanning. RESULTS: Overall and proximal gastric emptying were delayed in 47.3% (44/93) and 46.2% (43/93) of the patients, respectively. Logistic regression analyses showed that presence of nausea was associated with delayed proximal gastric emptying (odds ratio 4.951; 95% confidence interval 1.321, 18.558). There were no significant differences between normal and delayed overall gastric emptying according to presence of symptoms. CONCLUSIONS: Presence of nausea might indicate delayed gastric emptying of the proximal stomach. Promotion of proximal gastric emptying may constitute an effective therapy for patients with functional dyspepsia who report nausea as the dominant symptom.
基金：
National Key Technology R&D Programme in the 11th 5-Year Plan of China [2007BAI20B0901]
语种：
外文
被引次数：
WOS：
中科院(CAS)分区：
出版当年[2011]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
最新[2025]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
JCR分区：
出版当年[2010]版：
Q4PHARMACOLOGY & PHARMACYQ4MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q4MEDICINE, RESEARCH & EXPERIMENTALQ4PHARMACOLOGY & PHARMACY
第一作者单位：[1]China Japan Friendship Hosp, Minist Hlth, Dept Gastroenterol, Beijing 100029, Peoples R China[3]Peking Union Med Coll, Grad Sch, Beijing 100021, Peoples R China[4]Chinese Acad Med Sci, Beijing 100730, Peoples R China
通讯作者：
通讯机构：[1]China Japan Friendship Hosp, Minist Hlth, Dept Gastroenterol, Beijing 100029, Peoples R China[*1]China Japan Friendship Hosp, Minist Hlth, Dept Gastroenterol, 2 Yinghua E Rd, Beijing 100029, Peoples R China
推荐引用方式(GB/T 7714)：
Guo W-J,Yao S-K,Zhang Y-L,et al.Relationship between Symptoms and Gastric Emptying of Solids in Functional Dyspepsia[J].JOURNAL of INTERNATIONAL MEDICAL RESEARCH.2012,40(5):1725-1734.doi:10.1177/030006051204000511.
APA：
Guo, W-J,Yao, S-K,Zhang, Y-L,Yan, J.,Yin, L-J&Li, H-L.(2012).Relationship between Symptoms and Gastric Emptying of Solids in Functional Dyspepsia.JOURNAL of INTERNATIONAL MEDICAL RESEARCH,40,(5)
MLA：
Guo, W-J,et al."Relationship between Symptoms and Gastric Emptying of Solids in Functional Dyspepsia".JOURNAL of INTERNATIONAL MEDICAL RESEARCH 40..5(2012):1725-1734
