Objective: Regulatory T cell (Treg) and interleukin-2 (IL-2) are 2 important factors in the immune system. Our goal was to find out the frequency of Treg and IL-2 levels in different clinicopathological transitional cell carcinoma (TCC) patients and the relationship between them. Methods: We investigated the proportion of Treg and IL-2 levels from 65 patients with TCC, 38 with benign urinary diseases, and 37 healthy subjects, and analyzed different clinicopathologic characteristics and the changes before and after surgery. Results: We found the proportion of Treg from patients with TCC was significantly higher than the other 2 groups, and the IL-2 level in the TCC group was significantly decreased compared with the other 2 groups. Both Treg and IL-2 levels were correlated with surgery, tumor stage, number of tumors, metastasis, and recurrence. Conclusion: Regulatory T cell and IL-2 may be responsible for immune regulation and the result may also contribute to our understanding of immunotherapy in these patients.
第一作者单位：[1]Capital Med Univ, Friendship Hosp, Dept Urol, Beijing, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Zhu Xi,Ma Lin-Lin,Xiao Jing,et al.CD4+CD25(high)CD127(low/-) Regulatory T Cell and Interleukin 2 in Transitional Cell Carcinoma[J].LABMEDICINE.2011,42(3):163-167.doi:10.1309/LM44A9MBCAUSVRAD.
APA：
Zhu Xi,Ma Lin-Lin,Xiao Jing&Tian Ye.(2011).CD4+CD25(high)CD127(low/-) Regulatory T Cell and Interleukin 2 in Transitional Cell Carcinoma.LABMEDICINE,42,(3)
MLA：
Zhu Xi,et al."CD4+CD25(high)CD127(low/-) Regulatory T Cell and Interleukin 2 in Transitional Cell Carcinoma".LABMEDICINE 42..3(2011):163-167
