Background: Serine protease inhibitor member 3 of clade A (SERPINA3) has been shown as a risk factor for aneurysmal subarachnoid hemorrhage in a Polish population. In the present study, the authors investigated the correlation between the rs4934 polymorphism of SERPINA3 and sporadic intracranial aneurysms in Chinese patients. Methods: The rs4934 polymorphism of SERPINA3 was identified by PCR and Taqman MGB probe analysis in genomic DNA from 275 patients with sporadic intracranial aneurysms (mean age 50.83 +/- 10.78 years) and 361 control participants (mean age 53.21 +/- 10.81 years). Differences in allelic and genotypic frequencies between the patient and control groups were evaluated with the chi(2) test. Results: No significant difference was found in either the genotype distribution or allelic frequencies of SERPINA3 between patients and controls. Conclusions: The rs4934 polymorphism of SERPINA3 is not associated with sporadic intracranial aneurysms among individuals of Chinese Han ethnicity. Copyright (C) 2009 S. Karger AG, Basel
第一作者单位：[1]Shandong Univ, Prov Hosp, Dept Neurosurg, Jinan 250021, Shandong, Peoples R China
通讯作者：
通讯机构：[1]Shandong Univ, Prov Hosp, Dept Neurosurg, Jinan 250021, Shandong, Peoples R China[*1]Shandong Univ, Prov Hosp, Dept Neurosurg, 324 Jingwuweiqi Rd, Jinan 250021, Shandong, Peoples R China
推荐引用方式(GB/T 7714)：
Liu Wei,Zhu Yufang,Ge Mingxu,et al.Polymorphism rs4934 of SERPINA3 and Sporadic Intracranial Aneurysms in the Chinese Population[J].CEREBROVASCULAR DISEASES.2010,29(1):68-72.doi:10.1159/000256649.
APA：
Liu, Wei,Zhu, Yufang,Ge, Mingxu,Pang, Qi&Yu, Yanbing.(2010).Polymorphism rs4934 of SERPINA3 and Sporadic Intracranial Aneurysms in the Chinese Population.CEREBROVASCULAR DISEASES,29,(1)
MLA：
Liu, Wei,et al."Polymorphism rs4934 of SERPINA3 and Sporadic Intracranial Aneurysms in the Chinese Population".CEREBROVASCULAR DISEASES 29..1(2010):68-72
