单位：[1]China Japan Friendship Hosp, Natl Integrat Med Ctr Cardiovasc Dis, Beijing 100029, Peoples R China[2]Chino Acad Chinese Med Sci, Beijing 100700, Peoples R China[3]China Japan Friendship Hosp, Inst Clin Med Sci, Beijing 100029, Peoples R China
Type 2 diabetes is considered a "risk equivalent" for cardiovascular disease, rosiglitazone, as an insulin sensitizer, has been explored as a novel therapeutic drug for the prevention of cardiovascular disease, but whether it can stabilize vulnerable atherosclerotic plaques is still unknown. Our Study aims to investigate the effect of rosiglitazone on plaque stability in fat-fed ApoE-knockout mice. Our findings showed that rosiglitazone can stabilize the vulnerable atherosclerotic plaques in fat-fed ApoE-knockout mice by modifying the plaque composition as well as decreasing the number of buried fibrous caps and its anti-inflammatory effect probably is the key mechanism through which promotes the plaque more stable. Crown Copyright (C) 2008 Published by Elsevier B.V. All rights reserved.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30572302, 30672751]
第一作者单位：[2]Chino Acad Chinese Med Sci, Beijing 100700, Peoples R China
通讯作者：
通讯机构：[1]China Japan Friendship Hosp, Natl Integrat Med Ctr Cardiovasc Dis, Beijing 100029, Peoples R China[*1]China Japan Friendship Hosp, Natl Integrat Med Ctr Cardiovasc Dis, Ying Hua E Rd, Beijing 100029, Peoples R China
推荐引用方式(GB/T 7714)：
Zhou Mingxue,Xu Hao,Pan Lin,et al.Rosiglitazone promotes atherosclerotic plaque stability in fat-fed ApoE-knockout mice[J].EUROPEAN JOURNAL of PHARMACOLOGY.2008,590(1-3):297-302.doi:10.1016/j.ejphar.2008.05.041.
APA：
Zhou, Mingxue,Xu, Hao,Pan, Lin,Wen, Jianyan,Liao, Wenqiang&Chen, Keji.(2008).Rosiglitazone promotes atherosclerotic plaque stability in fat-fed ApoE-knockout mice.EUROPEAN JOURNAL of PHARMACOLOGY,590,(1-3)
MLA：
Zhou, Mingxue,et al."Rosiglitazone promotes atherosclerotic plaque stability in fat-fed ApoE-knockout mice".EUROPEAN JOURNAL of PHARMACOLOGY 590..1-3(2008):297-302
