单位：[1]Department of Radiology, Beijing Friendship Hospital, CapitalMedical University, Beijing 100050, China医技科室影像中心放射科首都医科大学附属北京友谊医院[2]Department of Radiology, Stanford University, 300 Pasteur Drive,Room S047, Stanford, CA 94305-5105, USA[3]Department of Mechanical Engineering, Stevens Institute ofTechnology, Hoboken, NJ 07030, USA[4]National Clinical Research Center for Digestive Diseases, BeijingFriendship Hospital, Capital Medical University, Beijing 100050,China首都医科大学附属北京友谊医院[5]Department of Mechanical Engineering, University of BritishColumbia, Vancouver, BC V6S0K4, Canada[6]Department of Biomedical Engineering, University of Arizona,Tucson, AZ 85721, USA[7]Department of Bioengineering, Stanford University,Stanford, CA 94305, USA
Objectives To analyze the mechanical properties in different regions of the brain in healthy adults in a wide age range: 26 to 76 years old. Methods We used a multifrequency magnetic resonance elastography (MRE) protocol to analyze the effect of age on frequency-dependent (storage and loss moduli,G ' andG '', respectively) and frequency-independent parameters (mu(1),mu(2), and eta, as determined by a standard linear solid model) of the cerebral parenchyma, cortical gray matter (GM), white matter (WM), and subcortical GM structures of 46 healthy male and female subjects. The multifrequency behavior of the brain and frequency-independent parameters were analyzed across different age groups. Results The annual change rate ranged from - 0.32 to - 0.36% forG ' and - 0.43 to - 0.55% forG '' for the cerebral parenchyma, cortical GM, and WM. For the subcortical GM, changes inG ' ranged from - 0.18 to - 0.23%, andG '' changed - 0.43%. Interestingly, males exhibited decreased elasticity, while females exhibited decreased viscosity with respect to age in some regions of subcortical GM. Significantly decreased values were also found in subjects over 60 years old. Conclusion Values ofG ' andG '' at 60 Hz and the frequency-independent mu(2)of the caudate, putamen, and thalamus may serve as parameters that characterize the aging effect on the brain. The decrease in brain stiffness accelerates in elderly subjects.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [61801311]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7182044]; Beijing Hospitals Authority [PX2018001]; Beijing Hospitals Authority Youth Programme [QML20180103]; Beijing Friendship Hospital, Capital Medical University [YYZZ2017B01]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2019 M660717]
医学