单位：[1]Department of Radiology, China-Japan Friendship Hospital, Beijing, China[2]Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China[3]Beijing Intelligent Brain Cloud Inc., Beijing, China[4]Department of Anesthesiology, Peking University First Hospital, Peking University, Beijing, China[5]Department of Science and Education, Shangluo Central Hospital, Shangluo, China[6]Beijing City Key Lab for Medical Physics and Engineering, Institute of Heavy Ion Physics, School of Physics, Peking University, Beijing, China[7]Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China[8]McGovern Institute for Brain Research, Peking University, Beijing, China
Most diffusion magnetic resonance imaging (dMRI) techniques use the mono-exponential model to describe the diffusion process of water in the brain. However, the observed dMRI signal decay curve deviates from the mono-exponential form. To solve this problem, the fractional motion (FM) model has been developed, which is regarded as a more appropriate model for describing the complex diffusion process in brain tissue. It is still unclear in the identification and classification of Alzheimer's disease (AD) patients using the FM model. The purpose of this study was to investigate the potential feasibility of FM model for differentiating AD patients from healthy controls and grading patients with AD. Twenty-four patients with AD and 11 healthy controls were included. The left and right hippocampus were selected as regions of interest (ROIs). The apparent diffusion coefficient (ADC) values and FM-related parameters, including the Noah exponent (alpha), the Hurst exponent (H), and the memory parameter (mu=H-1/alpha), were calculated and compared between AD patients and healthy controls and between mild AD and moderate AD patients using a two-samplet-test. The correlations between FM-related parameters alpha,H, mu, and ADC values and the cognitive functions assessed by mini-mental state examination (MMSE) and Montreal cognitive assessment (MoCA) scales were investigated using Pearson partial correlation analysis in patients with AD. The receiver-operating characteristic analysis was used to assess the differential performance. We found that the FM-related parameter alpha could be used to distinguish AD patients from healthy controls (P< 0.05) with greater sensitivity and specificity (left ROI, 0.917 and 0.636; right ROI, 0.917 and 0.727) and grade AD patients (P< 0.05) showed higher sensitivity and specificity (right ROI, 0.917, 0.75). The alpha was found to be positively correlated with MMSE (P< 0.05) and MoCA (P< 0.05) scores in patients with AD, indicating that the alpha values in the bilateral hippocampus were a potential MRI-based biomarker of disease severity in AD patients. This novel diffusion model may be useful for further understanding neuropathologic changes in patients with AD.
基金：
National Key Research and Development Program of China [2020YFC2003903, 2019YFC0120903, 2016YFC1307001]; National Natural Science Foundation of China (NSFC)National Natural Science Foundation of China (NSFC) [81971585, 81571641, 91959123]
第一作者单位：[1]Department of Radiology, China-Japan Friendship Hospital, Beijing, China[2]Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
通讯作者：
通讯机构：[1]Department of Radiology, China-Japan Friendship Hospital, Beijing, China[2]Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
推荐引用方式(GB/T 7714)：
Du Lei,Xu Boyan,Zhao Zifang,et al.Identification and Classification of Alzheimer's Disease Patients Using Novel Fractional Motion Model[J].FRONTIERS in NEUROSCIENCE.2020,14:doi:10.3389/fnins.2020.00767.
APA：
Du, Lei,Xu, Boyan,Zhao, Zifang,Han, Xiaowei,Gao, Wenwen...&Ma, Guolin.(2020).Identification and Classification of Alzheimer's Disease Patients Using Novel Fractional Motion Model.FRONTIERS in NEUROSCIENCE,14,
MLA：
Du, Lei,et al."Identification and Classification of Alzheimer's Disease Patients Using Novel Fractional Motion Model".FRONTIERS in NEUROSCIENCE 14.(2020)
