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A new Zn(II)-cluster coordination polymer: selective detection of Al(III) ion and treatment activity on hypotension after anesthesia by increasing alpha receptor expression

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收录情况： ◇ SCIE

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单位： [1]Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China [2]Department of Anesthesiology, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China

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关键词： Coordination polymer Detection sensor Hypotension Western blot

摘要：

In this research, a novel coordination polymer (CP) based on Zn(II) ions as nodes [Zn-2(1,4-NDC)(2)(py)(2)(H2O)] (1, py = pyridine and 1,4-NDCH2 = 1,4-naphthalenedicarboxylic acid) has been produced under hydrothermal reaction condition and then structurally characterized. Furthermore, Zn-complex reveals high sensitivity (with the detection limit of 1.97 x 10(-6) M) and fast test time for the Al(3+)in the water phase through the fluorescence enhancement method which is rare example in the reported Al(3+)detection sensors. The compound was designed for hypotension treatment after anesthesia. First of all, the hypotension animal model was constructed; then, the compound's protective was evaluated. The real-time reverse transcription-polymerase chain reaction (RT-PCR) was performed, and the alpha receptor expression on the vascular endothelial cells was determined. In addition to this, the western blot was also conducted for the alpha receptor expression assessment.

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出版当年[2020]版：

大类 | 4 区化学

小类 | 4 区化学综合

最新[2025]版：

大类 | 4 区化学

小类 | 4 区化学：综合

JCR分区：

出版当年[2019]版：

Q3 CHEMISTRY, MULTIDISCIPLINARY

最新[2023]版：

Q3 CHEMISTRY, MULTIDISCIPLINARY

影响因子： 最新[2023版] 2.2 最新五年平均[2021-2025] 2 出版当年[2019版] 1.552 出版当年五年平均[2015-2019] 1.433 出版前一年[2018版] 1.742 出版后一年[2020版] 2.019

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第一作者单位： [1]Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China

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