单位：[1]Department of Pulmonary and CriticalCare Medicine, Center of RespiratoryMedicine, China-Japan FriendshipHospital, Beijing, People’s Republic ofChina[2]National Clinical ResearchCenter for Respiratory Diseases, Beijing,People’s Republic of China[3]CapitalMedical University, Beijing, People’sRepublic of China[4]The Graduate Schoolof Peking Union Medical College, ChineseAcademy of Medical Science and PekingUnion Medical College, Beijing, People’sRepublic of China[5]Peking UniversityHealth Science Center, Beijing, People’sRepublic of China
Purpose: Prior studies have indicated that patients with chronic obstructive pulmonary disease (COPD) exhibit significant cognitive defects on neuropsychological testing. Obstructive sleep apnea (OSA) is common in patients with COPD and is associated with reduced cognitive function; however, the combined impact of these two conditions on cognitive function is unknown. The aim of the study was to investigate the impact of OSA on cognitive impairment in patients with COPD. Methods: Sixty-five stable COPD patients aged over 60 years underwent overnight polysomnography (PSG). Global cognitive functions were evaluated using the Mini-Mental State Examination (MMSE). Results: Compared to patients with COPD alone, patients with both COPD and OSA performed worse on the MMSE (25.5 +/- 2.9 vs 23.5 +/- 3.2; p=0.01) and were more likely to be at risk for developing dementia based on the MMSE score (MMSE <= 24) (31% vs 66%; p<0.01), independent of key demographic, educational and medical variables known to affect cognitive function in COPD. COPD patients with an apnea hypopnea index (AHI) of >= 30 events/h had lower M1VISE scores than those with an AHI of <15 events/h. In addition to age and education level, the severity of nocturnal intermittent hypoxia is an independent predictor of the risk of dementia in patients with COPD (OR=1.24, 95% CI 1.04-1.48, p = 0.02). Conclusion: The current findings indicate that patients with COPD with comorbid OSA may be at greater risk for global cognitive impairment relative to patients with COPD alone. The mechanisms underlying the exaggerated cognitive dysfunction seem to be related to intermittent hypoxia. Further work is needed to understand the impact of OSA on the specific domains of cognitive impairment and the therapeutic implications of OSA in COPD.
第一作者单位：[1]Department of Pulmonary and CriticalCare Medicine, Center of RespiratoryMedicine, China-Japan FriendshipHospital, Beijing, People’s Republic ofChina[2]National Clinical ResearchCenter for Respiratory Diseases, Beijing,People’s Republic of China[3]CapitalMedical University, Beijing, People’sRepublic of China[4]The Graduate Schoolof Peking Union Medical College, ChineseAcademy of Medical Science and PekingUnion Medical College, Beijing, People’sRepublic of China[5]Peking UniversityHealth Science Center, Beijing, People’sRepublic of China[*1]Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, People’s Republic of China
通讯作者：
通讯机构：[1]Department of Pulmonary and CriticalCare Medicine, Center of RespiratoryMedicine, China-Japan FriendshipHospital, Beijing, People’s Republic ofChina[2]National Clinical ResearchCenter for Respiratory Diseases, Beijing,People’s Republic of China[3]CapitalMedical University, Beijing, People’sRepublic of China[4]The Graduate Schoolof Peking Union Medical College, ChineseAcademy of Medical Science and PekingUnion Medical College, Beijing, People’sRepublic of China[5]Peking UniversityHealth Science Center, Beijing, People’sRepublic of China[*1]Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, People’s Republic of China
推荐引用方式(GB/T 7714)：
Zhang Xiao Lei,Gao Bo,Han Teng,et al.Moderate-to-Severe Obstructive Sleep Apnea and Cognitive Function Impairment in Patients with COPD[J].INTERNATIONAL JOURNAL of CHRONIC OBSTRUCTIVE PULMONARY DISEASE.2020,15:1813-1822.doi:10.2147/COPD.S257796.
APA：
Zhang, Xiao Lei,Gao, Bo,Han, Teng,Xiang, Bo Yun&Liu, Xin.(2020).Moderate-to-Severe Obstructive Sleep Apnea and Cognitive Function Impairment in Patients with COPD.INTERNATIONAL JOURNAL of CHRONIC OBSTRUCTIVE PULMONARY DISEASE,15,
MLA：
Zhang, Xiao Lei,et al."Moderate-to-Severe Obstructive Sleep Apnea and Cognitive Function Impairment in Patients with COPD".INTERNATIONAL JOURNAL of CHRONIC OBSTRUCTIVE PULMONARY DISEASE 15.(2020):1813-1822
