单位：[1]Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, 95th Yong’an Road, Xicheng District, Beijing 100050, China临床科室耳鼻咽喉头颈外科耳鼻咽喉头颈外科首都医科大学附属北京友谊医院[2]Department of Emergency, Aviation General Hospital, Beijing 100012, China
The chaperonin-containing T-complex protein 1 (CCT) subunits participate in diverse diseases. However, little is known about their expression and prognostic values in human head and neck squamous cancer (HNSC). This article aims to evaluate the effects of CCT subunits regarding their prognostic values for HNSC. We mined the transcriptional and survival data of CCTs in HNSC patients from online databases. A protein-protein interaction network was constructed and a functional enrichment analysis of target genes was performed. We observed that the mRNA expression levels of CCT1/2/3/4/5/6/7/8 were higher in HNSC tissues than in normal tissues. Survival analysis revealed that the high mRNA transcriptional levels of CCT3/4/5/6/7/8 were associated with a low overall survival. The expression levels of CCT4/7 were correlated with advanced tumor stage. And the over-expression of CCT4 was associated with higher N stage of patients. Validation of CCTs' differential expression and prognostic values was achieved by the Human Protein Atlas and GEO datasets. Mechanistic exploration of CCT subunits by the functional enrichment analysis suggests that these genes may influence the HNSC prognosis by regulating PI3K-Akt and other pathways. This study implies that CCT3/4/6/7/8 are promising biomarkers for the prognosis of HNSC.
基金：
Research and Development Project of Scientific Research Instruments and Equipment of the Chinese Academy of Sciences -major instruments project [YJKYYQ20180039]; Digestive Medical Coordinated Development Center of Beijing Municipal Administration of Hospitals [XXZ0604]
第一作者单位：[1]Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, 95th Yong’an Road, Xicheng District, Beijing 100050, China
通讯作者：
通讯机构：[1]Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, 95th Yong’an Road, Xicheng District, Beijing 100050, China[*1]Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, 95th Yong’an Road, Xicheng District, Beijing 100050, China
推荐引用方式(GB/T 7714)：
Dong Yanbo,Lu Siyu,Wang Zhenxiao,et al.CCTs as new biomarkers for the prognosis of head and neck squamous cancer[J].OPEN MEDICINE.2020,15(1):672-688.doi:10.1515/med-2020-0114.
APA：
Dong, Yanbo,Lu, Siyu,Wang, Zhenxiao&Liu, Liangfa.(2020).CCTs as new biomarkers for the prognosis of head and neck squamous cancer.OPEN MEDICINE,15,(1)
MLA：
Dong, Yanbo,et al."CCTs as new biomarkers for the prognosis of head and neck squamous cancer".OPEN MEDICINE 15..1(2020):672-688
