单位：[1]Department of Oncology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China,临床科室肿瘤中心肿瘤内科首都医科大学附属北京友谊医院[2]Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing, 100050, China临床科室国家中心消化分中心消化内科首都医科大学附属北京友谊医院
Ovarian serous adenocarcinoma is one of the most common and fatal malignancies among women worldwide. The tumor microenvironment plays a critical role in tumor initiation, proliferation, and metastasis. Immune scores and stromal scores of the tumor microenvironment were determined using the ESTIMATE. Immune cell infiltration was assessed using TIMER and differentially expressed genes (DEGs) were determined using the R/Bioconductor package of edgeR. Survival analysis was carried out using a univariate Cox model and Kaplan-Meier survival, and gene functional information was obtained through Gene Ontology and KEGG pathway analysis. Survival analysis revealed 39 DEGs that significantly influenced the prognosis of ovarian serous adenocarcinoma patients and were correlated with immune cell abundance. Functional enrichment and protein-protein interaction network analyses further indicated that these genes are primarily involved in immune-related responses. Finally, we verified the prognostic value of these genes via GEO. The present results reveal the genes associated with the tumor microenvironment of ovarian adenocarcinoma, potentially providing prognostic information.
基金：
National Natural Science Foundation of China [81670474]; Digestive Medical Coordinated Development Center of Beijing Hospitals Authority [XXT01]; China Population Publicity and Education Center Research and Promotion Project [2017-A001]
第一作者单位：[1]Department of Oncology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China,
通讯作者：
通讯机构：[2]Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing, 100050, China[*1]Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing, 100050, P. R. China.
推荐引用方式(GB/T 7714)：
Tian Ruyue,Zhao Guiping,Zhou Anni,et al.Prognostic gene profiles in the tumor microenvironment of ovarian serous adenocarcinoma[J].FRONTIERS in BIOSCIENCE-LANDMARK.2021,26(4):692-705.doi:10.2741/4913.
APA：
Tian Ruyue,Zhao Guiping,Zhou Anni,Li Huihui,Cao Bangwei&Guo Shuilong.(2021).Prognostic gene profiles in the tumor microenvironment of ovarian serous adenocarcinoma.FRONTIERS in BIOSCIENCE-LANDMARK,26,(4)
MLA：
Tian Ruyue,et al."Prognostic gene profiles in the tumor microenvironment of ovarian serous adenocarcinoma".FRONTIERS in BIOSCIENCE-LANDMARK 26..4(2021):692-705
