单位：[1]Center for Hearing and Deafness, State University of New York at Buffalo, Buffalo, New York[2]The Third People’s Hospital of Chengdu, Chengdu, China[3]Department of Otolaryngology, Beijing Friendship Hospital, Capital Medical University, Beijing, China首都医科大学附属北京友谊医院[4]Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China华中科技大学同济医学院附属协和医院[5]Xiangya Hospital, Central South University, Changsha, China[6]Huashan Hospital, Fudan University, Shanghai, China[7]Beijing Hospital and National Center of Gerontology, Department of Otolaryngology, Beijing, China[8]Shanghai Six People’s Hospital, Shanghai Jiao Tong University, Shanghai, China[9]The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China中山大学附属第三医院[10]YouHear Academy, Guangzhou, China
Ding D, Zhang J, Li W, Li D, Yu J, Wu X, Qi W, Liu F, Jiang H, Shi H, Sun H, Li P, Huang W, Salvi R. Can auditory brain stem response accurately reflect the cochlear function? J Neurophysiol 124: 1667-1675, 2020. First published October 7, 2020; doi:10.1152/jn.00233.2020.-Auditory brain stem response (ABR) and compound action potential (CAP) recordings have been used in animal research to determine hearing sensitivity. Because of the relative ease of testing, the ABR test has been more commonly used in assessing cochlear lesions than the CAP test. The purpose of this experiment is to examine the difference between these two meth-ods in monitoring the dynamic changes in auditory function after cochlear damage and in detecting asymmetric hearing loss due to unilateral cochlear damage. ABR and CAP were measured in two models of cochlear damage: acoustic trauma induced by exposure to a narrowband noise centered at 4 kHz (2,800-5,600 Hz) at 105 dB sound pressure level for 5 h in chinchillas and unilateral cochlear damage induced by surgical destruction of one cochlea in guinea pigs. Cochlear hair cells were quantified after completing the evoked potential testing. In the noise-damaged model, we found different re-covery patterns between ABR and CAP. At 1 day after noise expo -sure, the ABR and CAP assessment revealed a similar level of threshold shifts. However, at 30 days after noise exposure, ABR thresholds displayed an average of 20-dB recovery, whereas CAP thresholds showed no recovery. Notably, the CAP threshold signifies the actual condition of sensory cell pathogenesis in the cochlea because sensory cell death is known to be irreversible in mammals. After unilateral cochlear damage, we found that both CAP and ABR were affected by cross-hearing when testing the damaged ear with the testing stimuli delivered directly into the canal of the damaged ear. When cross-hearing occurred, ABR testing was not able to reveal the presence of cross-hearing because the ABR waveform generated by cross-stimulation was indistinguishable from that gener-ated by the test ear (damaged ear), should the test ear be intact. However, CAP testing can provide a warning sign, since the typical CAP waveform became an ABR-like waveform when cross-hearing occurred. Our study demonstrates two advantages of the CAP test over the ABR test in assessing cochlear lesions: contributing evi-dence for the occurrence of cross-hearing when subjects have asym-metric hearing loss and providing a better assessment of the progression of cochlear pathogenesis. NEW & NOTEWORTHY Auditory brain stem response (ABR) is more commonly used to evaluate cochlear lesions than cochlear compound action potential (CAP). In a noise-induced cochlear dam-age model, we found that the reduced CAP and enhanced ABR caused the threshold difference. In a unilateral cochlear destruction model, a shadow curve of the ABR from the contralateral healthy ear masked the hearing loss in the destroyed ear.
基金：
NIH, National Institute on Deafness and Other Communication DisordersUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Deafness & Other Communication Disorders (NIDCD) [R01DC014437]; Science and Technology Commission of Shanghai MunicipalityScience & Technology Commission of Shanghai Municipality (STCSM) [15140900900]
第一作者单位：[1]Center for Hearing and Deafness, State University of New York at Buffalo, Buffalo, New York[2]The Third People’s Hospital of Chengdu, Chengdu, China[8]Shanghai Six People’s Hospital, Shanghai Jiao Tong University, Shanghai, China
共同第一作者：
通讯作者：
通讯机构：[1]Center for Hearing and Deafness, State University of New York at Buffalo, Buffalo, New York[2]The Third People’s Hospital of Chengdu, Chengdu, China[8]Shanghai Six People’s Hospital, Shanghai Jiao Tong University, Shanghai, China
推荐引用方式(GB/T 7714)：
Ding Dalian,Zhang Jianhui,Li Wenjuan,et al.Can auditory brain stem response accurately reflect the cochlear function?[J].JOURNAL of NEUROPHYSIOLOGY.2020,124(6):1667-1675.doi:10.1152/jn.00233.2020.
APA：
Ding Dalian,Zhang Jianhui,Li Wenjuan,Li Dong,Yu Jintao...&Richard Salvi.(2020).Can auditory brain stem response accurately reflect the cochlear function?.JOURNAL of NEUROPHYSIOLOGY,124,(6)
MLA：
Ding Dalian,et al."Can auditory brain stem response accurately reflect the cochlear function?".JOURNAL of NEUROPHYSIOLOGY 124..6(2020):1667-1675
