Lymphoma-associated haemophagocytic lymphohistiocytosis (LA-HLH) has a poor prognosis. Currently, there is no unified, effective first-line treatment regimen for it. We retrospectively analyzed the clinical data of 50 patients who received the DEP regimen and 30 patients who received the HLH-1994 regimen. After 2 weeks of treatment, the ORR of the DEP group was higher than that of the HLH-1994 group (p = 0.024). After 4 weeks, the CR and ORR of the DEP group were higher than those of the HLH-1994 group (p < 0.05). The recurrence rate of the HLH-1994 group within 4 weeks (20.0%) was higher than that of the DEP group (2.1%) (p < 0.05). The median survival of patients with NK/T and T-cell lymphoma in the DEP group (10.1 months) was longer than the median survival of the HLH-1994 group (2.6 months) (p = 0.017). Our study suggests that the DEP regimen can improve Week 2 and Week 4 ORR, Week 4 CR, and reduce Week 4 recurrence rate for LA-HLH more than the HLH-1994 regimen.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81871633]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7181003]; Beijing Municipal Administration of Hospitals' Ascent Plan [DFL20180101]
第一作者单位：[1]Department of Hematology, Beijing Friendship Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[1]Department of Hematology, Beijing Friendship Hospital, Capital Medical University, Beijing, China[*1]Department of Hematology, Beijing Friendship Hospital, Capital Medical University, 95 Yong An Road, Xicheng District, Beijing 100050, China
推荐引用方式(GB/T 7714)：
Meng G,Wang Y,Wang J,et al.The DEP regimen is superior to the HLH-1994 regimen as first-line therapy for lymphoma-associated haemophagocytic lymphohistiocytosis[J].LEUKEMIA & LYMPHOMA.2021,62(4):854-860.doi:10.1080/10428194.2020.1849671.
APA：
Meng, G,Wang, Y,Wang, J&Wang, Z.(2021).The DEP regimen is superior to the HLH-1994 regimen as first-line therapy for lymphoma-associated haemophagocytic lymphohistiocytosis.LEUKEMIA & LYMPHOMA,62,(4)
MLA：
Meng, G,et al."The DEP regimen is superior to the HLH-1994 regimen as first-line therapy for lymphoma-associated haemophagocytic lymphohistiocytosis".LEUKEMIA & LYMPHOMA 62..4(2021):854-860
