单位：[1]Department of Oncology, Beijing Friendship Hospital, Capital Medical University, #95 Yong An Road, Xicheng District, Beijing 100050, China临床科室肿瘤中心肿瘤内科首都医科大学附属北京友谊医院[2]Department of Comprehensive Medicine, Beijing Shijingshan Hospital, #24 Shijingshan Road, Shijingshan District, Beijing 100043, China[3]Yale School of Medicine, New Haven, CT, USA.
Digestive system cancers are associated with high morbidity and mortality. Chemotherapy and radiotherapy are the main treatment modalities for these cancers. However, the development of therapy resistance leads to high rates of tumor recurrence and metastasis, resulting in dismal prognosis. Long non-coding RNA (LncRNA) H19, one of the most intriguing non-coding RNAs, has been shown to play a key role in the development and therapy resistance of various digestive system cancers (including hepatocellular carcinoma, colorectal cancer, pancreatic ductal adenocarcinoma, esophageal carcinoma, gastric cancer, and biliary system cancer) by regulating the abnormal expression of genes. In this review, we discuss the potential mechanisms of LncRNA H19 related therapy resistance in the context of digestive system cancers. LncRNA H19 is a potential novel therapeutic target for amelioration of cancer therapy resistance.
基金：
Digestive Medical Coordinated Development Center of Beijing Hospitals Authority [XXT01]; Beijing key clinical specialty (2018-2020); pilot project of clinical collaboration with traditional Chinese medicine and western medicine in major refractory disease-Esophageal cancer [2019-ZX-005]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类|3 区医学
小类|3 区生化与分子生物学3 区医学：研究与实验4 区细胞生物学
最新[2025]版：
大类|2 区医学
小类|2 区生化与分子生物学2 区细胞生物学2 区医学：研究与实验
JCR分区：
出版当年[2019]版：
Q2CELL BIOLOGYQ2MEDICINE, RESEARCH & EXPERIMENTALQ2BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2023]版：
Q1BIOCHEMISTRY & MOLECULAR BIOLOGYQ1MEDICINE, RESEARCH & EXPERIMENTALQ2CELL BIOLOGY
第一作者单位：[1]Department of Oncology, Beijing Friendship Hospital, Capital Medical University, #95 Yong An Road, Xicheng District, Beijing 100050, China
通讯作者：
通讯机构：[1]Department of Oncology, Beijing Friendship Hospital, Capital Medical University, #95 Yong An Road, Xicheng District, Beijing 100050, China[3]Yale School of Medicine, New Haven, CT, USA.
推荐引用方式(GB/T 7714)：
Wang Jingting,Ma Xiao,Si Hai,et al.Role of long non-coding RNA H19 in therapy resistance of digestive system cancers[J].MOLECULAR MEDICINE.2021,27(1):doi:10.1186/s10020-020-00255-2.
APA：
Wang, Jingting,Ma, Xiao,Si, Hai,Ma, Zhongjun,Ma, Yan...&Cao, Bangwei.(2021).Role of long non-coding RNA H19 in therapy resistance of digestive system cancers.MOLECULAR MEDICINE,27,(1)
MLA：
Wang, Jingting,et al."Role of long non-coding RNA H19 in therapy resistance of digestive system cancers".MOLECULAR MEDICINE 27..1(2021)
医学