单位：[1]Liver Transplantation Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.临床科室国家中心普外分中心普外四科（肝脏移植外科）首都医科大学附属北京友谊医院[2]Clinical Center for Pediatric Liver Transplantation, Capital Medical University, Beijing, China.[3]Intensive Care Unit, Beijing Friendship Hospital, Capital Medical University, Beijing, China.临床科室急危重症及感染医学中心重症医学科首都医科大学附属北京友谊医院[4]National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, China.首都医科大学附属北京友谊医院
The objective of this meta-analysis was to assess the incidence of de novo autoimmune hepatitis (AIH) in children and adolescents with increased autoantibodies after liver transplantation. We systematically retrieved studies from PubMed, Embase, Central, CNKI, VIP and Wanfang published before February 1, 2020. All analyses were conducted using R-4.0.1 statistical package (Meta). Seven studies with high quality were pooled in our final analysis (N = 251 participants). The incidence of de novo AIH was 9% [95% confidence interval (CI) 1-23%, I-2 = 86%]. Subgroup analysis suggested that publications not using the International Autoimmune Hepatitis Group (IAIHG) criteria have marginally significantly higher incidence of de novo AIH than those using IAIHG criteria (P for interaction = 0.08). The incidence of chronic rejection was 8% (95% CI 2-17%, I-2 = 72%). Meta-regression indicated significant correlation (P = 0.04; estimate: 1.51) between the incidence of de novo AIH and the rate of increase of antibodies to liver/kidney microsome (anti-LKM). It is still challenging to distinguish de novo AIH and chronic rejection in children and adolescents with increased autoantibodies after liver transplantation. The diagnostic criteria for de novo AIH in children and adolescents and the role of anti-LKM in the development of de novo AIH deserve future investigation.
基金：
Beijing Municipal Science & Technology CommissionBeijing Municipal Science & Technology Commission [Z181100001718220]
第一作者单位：[1]Liver Transplantation Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.[2]Clinical Center for Pediatric Liver Transplantation, Capital Medical University, Beijing, China.[3]Intensive Care Unit, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
通讯作者：
通讯机构：[1]Liver Transplantation Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.[2]Clinical Center for Pediatric Liver Transplantation, Capital Medical University, Beijing, China.[3]Intensive Care Unit, Beijing Friendship Hospital, Capital Medical University, Beijing, China.[4]National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, China.[*1]Liver Transplantation Center, National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, 95 Yong An Road, Xi-Cheng District, Beijing 100050, China.
推荐引用方式(GB/T 7714)：
Ma Lin,Li Ming,Zhang Ting,et al.Incidence of de novo autoimmune hepatitis in children and adolescents with increased autoantibodies after liver transplantation: a meta-analysis[J].TRANSPLANT INTERNATIONAL.2021,34(3):412-422.doi:10.1111/tri.13801.
APA：
Ma Lin,Li Ming,Zhang Ting,Xu Jia-Qi,Cao Xue-Bin...&Sun Li-Ying.(2021).Incidence of de novo autoimmune hepatitis in children and adolescents with increased autoantibodies after liver transplantation: a meta-analysis.TRANSPLANT INTERNATIONAL,34,(3)
MLA：
Ma Lin,et al."Incidence of de novo autoimmune hepatitis in children and adolescents with increased autoantibodies after liver transplantation: a meta-analysis".TRANSPLANT INTERNATIONAL 34..3(2021):412-422
