单位：[1]Laboratory of Clinical Microbiology and Infectious Diseases, Department of Pulmonary and Critical Care Medicine, China- Japan Friendship Hospital, Beijing, China[2]Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing, China[3]Laboratory of Clinical Microbiology and Infectious Diseases, National Clinical Research Center of Respiratory Diseases, Beijing, China[4]Department of Laboratory Medicine, Zhengzhou Key Laboratory of Children’s Infection and Immunity, Children’s Hospital Affiliated to Zhengzhou University, Zhengzhou, China[5]Department of Laboratory Medicine, Tangshan Maternal and Child Health Care Hospital, Tangshan, China[6]Department of Laboratory Medicine, Civil Aviation General Hospital, Beijing, China[7]Department of Laboratory Medicine, Peking University First Hospital, Beijing, China[8]Department of Laboratory Medicine, People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, China[9]National Institute for Communicable Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Chinese Centre for Disease Control and Prevention, Beijing, China[10]Department of Laboratory Medicine, Beijing Anzhen Hospital, Beijing, China首都医科大学附属安贞医院[11]Department of Laboratory Medicine, Henan Provincial People’s Hospital, Zhengzhou, China[12]Department of Laboratory Medicine, Tai’an City Central Hospital, Tai'an, China[13]Department of Laboratory Medicine, Beijing Tongzhou District Maternal and Child Healthcare Hospital, Beijing, China[14]Department of Laboratory Medicine, First Affiliated Hospital of Xiamen University, Xiamen, China[15]Department of Laboratory Medicine, Daqing Oilfield General Hospital, Daqing, China[16]Department of Laboratory Medicine, Fifth People’s Hospital of Chengdu, Chengdu, China[17]Department of Laboratory Medicine, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China浙江大学医学院附属第一医院[18]Department of Laboratory Medicine, Chui Yang Liu Hospital Affiliated to Tsinghua University, Beijing, China[19]Department of Laboratory Medicine, Beijing Tsinghua Chang Gung Hospital, Tsinghua University, Beijing, China[20]Clinical Laboratory Medical Center, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China[21]Department of Laboratory Medicine, Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, China[22]Department of Laboratory Medicine, Hainan General Hospital, Haikou, China[23]Department of Laboratory Medicine, The Affiliated Tumor Hospital of Harrbin Medical University, Harbin, China[24]Department of Laboratory Medicine, Liuyang City Traditional Chinese Medicine Hospital, Liuyang, China[25]Department of Laboratory Medicine, Xiangtan Central Hospital, Xiangtan, China[26]Department of Laboratory Medicine, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China[27]Department of Laboratory Medicine, Weifang People’s Hospital, Weifang, China[28]Department of Laboratory Medicine, Wuhan Pu Ai Hospital of Huazhong University of Science and Technology, Wuhan, China[29]Department of Laboratory Medicine, Ningde Hospital, Fujian Medical University, Ningde, China
Listeriosis, caused by Listeria monocytogenes, is a severe food-borne infection. The nationwide surveillance in China concerning listeriosis is urgently needed. In the present study, 144 L. monocytogenes isolates were collected from the samples of blood, cerebrospinal fluid (CSF), and fetal membrane/placenta in China for 12 years from 2008 to 2019. We summarized these listeriosis patients' demographical and clinical features and outcomes. The susceptibility profile for 12 antibiotics was also determined by the broth microdilution method. Multilocus sequence typing (MLST) and serogroups of these listeria isolates were analyzed to designate epidemiological types. We enrolled 144 cases from 29 healthcare centers, including 96 maternal-neonatal infections, 33 cases of bacteremia, 13 cases of neurolisteriosis, and two cutaneous listeriosis. There were 31 (59.6%) fetal loss in 52 pregnant women and four (9.8%) neonatal death in 41 newborns. Among the 48 nonmaternal-neonatal cases, 12.5% (6/48) died, 41.7% (20/48) were female, and 64.6% (31/48) occurred in those with significant comorbidities. By MLST, the strains were distinguished into 23 individual sequence types (STs). The most prevalent ST was ST87 (49 isolates, 34.0%), followed by ST1 (18, 12.5%), ST8 (10, 6.9%), ST619 (9, 6.3%), ST7 (7, 4.9%) and ST3 (7, 4.9%). Furthermore, all L. monocytogenes isolates were uniformly susceptible to penicillin, ampicillin, and meropenem. In summary, our study highlights a high genotypic diversity of L. monocytogenes strains causing clinical listeriosis in China. Furthermore, a high prevalence of ST87 and ST1 in the listeriosis should be noted.
基金：
Beijing Municipal Science &Technology Commission, PR ChinaBeijing Municipal Science & Technology Commission [Z171100001017118]
第一作者单位：[1]Laboratory of Clinical Microbiology and Infectious Diseases, Department of Pulmonary and Critical Care Medicine, China- Japan Friendship Hospital, Beijing, China[2]Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing, China[3]Laboratory of Clinical Microbiology and Infectious Diseases, National Clinical Research Center of Respiratory Diseases, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Laboratory of Clinical Microbiology and Infectious Diseases, Department of Pulmonary and Critical Care Medicine, China- Japan Friendship Hospital, Beijing, China[2]Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing, China[3]Laboratory of Clinical Microbiology and Infectious Diseases, National Clinical Research Center of Respiratory Diseases, Beijing, China
推荐引用方式(GB/T 7714)：
Lu Binghuai,Yang Junwen,Gao Chunyan,et al.Listeriosis Cases and Genetic Diversity of Their L. monocytogenes Isolates in China, 2008-2019[J].FRONTIERS in CELLULAR and INFECTION MICROBIOLOGY.2021,11:doi:10.3389/fcimb.2021.608352.
APA：
Lu, Binghuai,Yang, Junwen,Gao, Chunyan,Li, Dong,Cui, Yanchao...&Zhong, Wen.(2021).Listeriosis Cases and Genetic Diversity of Their L. monocytogenes Isolates in China, 2008-2019.FRONTIERS in CELLULAR and INFECTION MICROBIOLOGY,11,
MLA：
Lu, Binghuai,et al."Listeriosis Cases and Genetic Diversity of Their L. monocytogenes Isolates in China, 2008-2019".FRONTIERS in CELLULAR and INFECTION MICROBIOLOGY 11.(2021)
