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Melatonin attenuates restenosis after vascular injury in diabetic rats through activation of the Nrf2 signaling pathway

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收录情况： ◇ SCIE

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单位： [a]Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China [b]Department of Vascular Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China [c]Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China

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关键词： Diabetes mellitus Restenosis Neointimal hyperplasia Vascular smooth muscle cells Nrf2 Oxidative stress Melatonin

摘要：

Diabetes is a major risk factor for the development of cardiovascular disease. Diabetic patients have a higher incidence of restenosis following endovascular therapy than non-diabetic patients. Melatonin is primarily synthesized and secreted by the pineal gland and plays an important protective antiinflammatory and antioxidant role in a variety of cardiovascular diseases. However, no studies to date have evaluated the underlying effects and molecular mechanisms of melatonin on diabetes-related restenosis. Herein, we used an in vivo model of diabetes-related restenosis and an in vitro model of high glucose-cultured vascular smooth muscle cells to investigate the anti-restenosis effect and signaling mechanisms induced by melatonin treatment. The present study provides the first evidence that melatonin attenuates restenosis following vascular injury in diabetic rats. We further investigated the underlying molecular mechanisms both in vivo and in vitro. The data suggest that the Nrf2 signaling pathway is an important molecular target for melatonin-mediated inhibition of diabetes-related restenosis after vascular injury. These findings indicate that melatonin may represent a potential candidate for the prevention or treatment of vascular diseases and restenosis following endovascular therapy, especially in diabetic patients. (c) 2021 Published by Elsevier Inc.

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出版当年[2020]版：

大类 | 3 区生物

小类 | 3 区生物物理 4 区生化与分子生物学

最新[2025]版：

大类 | 4 区生物学

小类 | 4 区生化与分子生物学 4 区生物物理

JCR分区：

出版当年[2019]版：

Q2 BIOPHYSICS Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS

影响因子： 最新[2023版] 2.5 最新五年平均[2021-2025] 2.7 出版当年[2019版] 2.985 出版当年五年平均[2015-2019] 2.75 出版前一年[2018版] 2.705 出版后一年[2020版] 3.575

第一作者：

第一作者单位： [a]Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China [b]Department of Vascular Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China

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通讯作者：

通讯机构： [a]Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China [*1]Department of Vascular Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, No. 1, Shuaifuyuan, Wangfujing Street, Beijing, 100730, China.

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