Objective: The objective of this study was to systematically evaluate the clinical efficacy of the integration method of heat-clearing, dampness-excreting, spleen-strengthening, and stasis-removing from traditional Chinese medicine (TCM) combined with Western medicine for the treatment of ulcerative colitis (UC). Materials and Methods: The databases China National Knowledge Infrastructure, China Biology Medicine disc (CBMdisc), WANFANG, VIP, and PubMed were searched for randomized controlled trials investigating the integration of the TCM methods of clearing heat, draining dampness, invigorating the spleen, and removing stasis, combined with Western medicine to treat UC from January 2009 to March 2019. Two reviewers independently conducted literature searches, screenings, data extractions, and literature bias evaluations. A meta-analysis was conducted using RevMan 5.3 and Stata 13.0 software. Results: In total, 15 studies involving 1289 patients were included. The results of the meta-analysis showed that the total effective rate of treatment in the experimental groups was higher than that of the control groups (relative risk [RR] = 1.27, 95% confidence interval [CI]: 1.21, 1.35, Z = 8.74,P < 0.00001). In the subgroup analysis, the total effective rate of oral TCM combined with Western medicine was higher than that of the control groups (RR = 1.24, 95% CI: 1.15, 1.33, Z = 5.88,P < 0.00001). The total effective rate of oral TCM with enemas combined with Western medicine was higher than that of the control group (RR = 1.30, 95% CI: 1.12, 1.50, Z = 3.52,P= 0.0004). The comparison between Western medicine alone and oral TCM combined with enteroscopy and Western medicine showed that the effective rate of enteroscopy (RR = 1.18, 95% CI: 1.05, 1.33, Z = 2.86,P= 0.004) and the symptom scores before and after treatment all improved more in the combined treatment groups than in those of the Western medicine group alone, with statistically significant differences (RR = -4.23, 95% CI: -4.93, -3.53, Z = 11.84,P < 0.00001). Conclusion: The integration of the TCM methods of heat clearing, dampness excreting, spleen strengthening, and stasis removing combined with Western medicine can significantly improve the cure rate of UC, and is an effective method to treat UC.