Xuebijing injection in septic rats mitigates kidney injury, reduces cortical microcirculatory disorders, and suppresses activation of local inflammation
单位：[1]Department of Critical Care Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China首都医科大学附属北京友谊医院[2]National Center for Trauma Medicine, Key Laboratory of Trauma and Neural Regeneration, Trauma Center, Peking University People’s Hospital, Beijing, 100000, China
Ethnopharmacological relevance: Xuebijing injections originate from the traditional Chinese medicine (TCM) prescription XuefuZhuyu Decoction. It is composed of five Chinese herbal extracts; Carthami fios, Paeoniae radix rubra, Chuanxiong rhizoma, Salviae miltiorrhizae, and Angelicae Sinensis radix. The China Food and Drug Administration approved Xuebijing injections as a TCM preparation for the adjuvant treatment of sepsis. Aim of the study: This study aims to determine the effects of Xuebijing injections as an adjuvant to antibiotics for the treatment of renal microcirculatory dysfunction and renal inflammation in rats with sepsis. Materials and methods: The rats received a sham operation (Sham), sham operation followed by Xuebijign injection (Sxbj), cecal ligation and puncture (CLP), or CLP followed by Xuebijing injection (Cxbj). Renal microvascular perfusion in the cortex and oxygenation were assessed at different times after sepsis induction. Renal levels of interleukin (IL)-113, IL-6, tumor necrosis factor (TNF)-alpha, and high mobility group box (HMGB)-1 were measured. Urinary TIMP-2 & times; IGFBP-7 and neutrophil gelatinase-associated lipocalin (NGAL) were measured as kidney biomarkers, and serum creatinine (SCr) was used to assess kidney injury. Tissue samples were stained for histologic evaluation. Results: The induction of sepsis increased local inflammation and decreased renal microvascular perfusion and oxygenation. Compared with the CLP group, the Cxbj group displayed improvements in microvascular perfusion and oxygenation (p < 0.05). The CLP group had significant increases in renal inflammatory biomarkers (IL-113, IL6, TNF-alpha, and HMGB-1; p < 0.05) and Xuebijing injection reduced the levels of these markers. The levels of urinary TIMP-2 & times; IGFBP-7, NAGL, and SCr were lower in the Cxbj group than in the CLP group (p < 0.05), and the CLP group had a higher Paller score than the Cxbj group (p < 0.05). However, the CLP and Cxbj groups had no significant difference in mortality. Conclusions: This study into the early stages of sepsis in a rat model indicated that as an adjuvant therapy to antibiotics, Xuebijing injection improved renal perfusion and oxygenation, suppressed renal inflammation, and ameliorated kidney dysfunction. However, Xuebijing injection had no impact on mortality.
第一作者单位：[1]Department of Critical Care Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China
通讯作者：
通讯机构：[1]Department of Critical Care Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China[*1]Department of Critical Care Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing China. No. 95 Yong An Road, Xi Cheng District, Beijing, 100050, China.
推荐引用方式(GB/T 7714)：
Liu Jingfeng,Wang Zhenzhou,Lin Jin,et al.Xuebijing injection in septic rats mitigates kidney injury, reduces cortical microcirculatory disorders, and suppresses activation of local inflammation[J].JOURNAL of ETHNOPHARMACOLOGY.2021,276:doi:10.1016/j.jep.2021.114199.
APA：
Liu Jingfeng,Wang Zhenzhou,Lin Jin,Li Tian,Guo Xinjie...&Duan Meili.(2021).Xuebijing injection in septic rats mitigates kidney injury, reduces cortical microcirculatory disorders, and suppresses activation of local inflammation.JOURNAL of ETHNOPHARMACOLOGY,276,
MLA：
Liu Jingfeng,et al."Xuebijing injection in septic rats mitigates kidney injury, reduces cortical microcirculatory disorders, and suppresses activation of local inflammation".JOURNAL of ETHNOPHARMACOLOGY 276.(2021)
