单位：[1]Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China,华中科技大学同济医学院附属同济医院[2]Department of Genetics and Endocrinology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China,[3]Department of Endocrinology and Genetic, Henan Provincial Children’s Hospital, Zhengzhou, China,[4]Department of Endocrine and Genetic Metabolism Disease, Children’s Hospital of Chongqing Medical University, Chongqing, China,[5]Department of Pediatrics, The First Affiliated Hospital, Jilin University, Changchun, China,[6]Department of Endocrinology, Metabolism, and Genetics, Children’s Hospital of Nanchang University & Jiangxi Provincial Children’s Hospital, Nanchang, China,[7]Department of Pediatrics, The Second Affiliated Hospital of Hebei Medical University, Shijiazhuang, China,[8]Department of Endocrinology, Shenzhen Children’s Hospital, Shenzhen, China,深圳市康宁医院深圳医学信息中心[9]Department of Endocrinology, Wuhan Children’s Hospital, Wuhan, China,[10]Department of Endocrinology, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China,[11]Department of Pediatrics Endocrinology, Xi’an Children’s Hospital, Xi’an, China,[12]Department of Pediatrics, The First Affiliated Hospital, Harbin Medical University, Harbin, China,[13]Department of Pediatrics, General Hospital of Tianjin Medical University, Tianjin, China,[14]Department of Pediatrics, Qingdao Women and Children’s Hospital, Qingdao University, Qingdao, China,[15]Department of Pediatrics, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China,[16]Department of Endocrinology, Shanghai Children’s Hospital, Shanghai Jiao Tong University, Shanghai, China,[17]Department of Pediatrics Endocrinology, Shengjing Hospital of China Medical University, Shenyang, China,中国医科大学附属盛京医院[18]Department of Endocrinology, Qilu Children’s Hospital, Shandong University, Jinan, China,[19]Department of Pediatrics, The Second Affiliated Hospital, Nanjing Medical University, Nanjing, China,[20]Department of Pediatrics, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China,[21]Department of Endocrinology, Fuzhou Children’s Hospital, Fuzhou, China,[22]Department of Pediatrics, The First Affiliated Hospital, Sun Yatsen University, Guangzhou, China,院本部南沙医院东院儿科儿科儿科儿科儿科中山大学附属第一医院[23]Department of Endocrinology and Metabolism, Chengdu Women’s and Children’s Central Hospital, Chengdu, China,[24]Department of Pediatric Endocrinology and Inherited Metabolic Diseases, Children’s Hospital of Fudan University, Shanghai, China,[25]Endocrinology, Genetics, and Metabolism, Beijing Diabetes Center for Children and Adolescents, Medical Genetics Department, Beijing Children’s Hospital, Beijing, China,首都医科大学附属北京儿童医院[26]Department of Pediatric Endocrinology, Shanxi Provincial Children’s Hospital, Taiyuan, China,[27]Department of Endocrinology, Children’s Hospital of Capital Institute of Pediatrics, Beijing, China,首都儿科研究所[28]Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China,[29]Department of Endocrinology, Hunan Provincial Children’s Hospital, Changsha, China,[30]Department of Pediatrics, Shandong Provincial Hospital, Jinan, China,[31]Department of Pediatrics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China,中山大学附属第二医院[32]Department of Pediatrics, The First Affiliated Hospital, Xinjiang Medical University, Urumqi, China,[33]Paediatric Endocrinology, Genetics, and Metabolism, Virtus Medical Group and The University of Hong Kong, Hong Kong SAR, China
Purpose To investigate the features and treatment status of children with type 1 diabetes mellitus (T1DM) in China. Methods We recruited patients Results A total of 1,603 children (755 males and 848 females) with T1DM participated in this survey. Of these, 834 (52.03%) of the patients exhibited diabetic ketoacidosis (DKA) at onset, while 769 patients (47.97%) did not exhibit DKA (non-DKA) at onset. There was a higher proportion of females (55.71%) in the cohort of patients exhibiting DKA at onset than in the non-DKA cohort (49.33%). The mean age of patients exhibiting DKA at presentation was 7.12 +/- 0.14 years; this was significantly younger than that in non-DKA group (7.79 +/- 0.15 years; P < 0.005). The frequency of DKA in 3 years old, 3-7 years old, and 7 years old or more was 77.21%, 26.17%, and 37.62%, respectively. Upon initial diagnosis, 29.4%, 15.2% and 11.8% of patients showed positivity for glutamic acid decarboxylase antibody (GADA), Insulin autoantibodies (IAA), or islet cell antibody (ICA), respectively. During six months follow-up, 244 patients (15.21%) reported receiving insulin pump therapy, and more than 60% of patients monitored their blood glucose levels less than 35 times per week. Although the majority of patients had no problems with obtaining insulin, 4.74% of the children surveyed were not able to receive insulin due to financial reasons, a shortage of insulin preparations, or the failure of the parents or guardians to acquire the appropriate medicine. Conclusion DKA is more common in very young children. Treatment and follow-up of T1DM in China still face very serious challenges.
基金：
World Diabetes Foundation [WDF11-617]; Ministry of Science and Technology [2017ZX09304022]
第一作者单位：[1]Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China,
通讯作者：
推荐引用方式(GB/T 7714)：
Ling Hou,Xiuzhen Li,Li Liu,et al.A Multicenter Survey of Type I Diabetes Mellitus in Chinese Children[J].FRONTIERS in ENDOCRINOLOGY.2021,12:doi:10.3389/fendo.2021.583114.
APA：
Ling Hou,Xiuzhen Li,Li Liu,Hanyang Wei,Feng Xiong...&Xiaoping Luo.(2021).A Multicenter Survey of Type I Diabetes Mellitus in Chinese Children.FRONTIERS in ENDOCRINOLOGY,12,
MLA：
Ling Hou,et al."A Multicenter Survey of Type I Diabetes Mellitus in Chinese Children".FRONTIERS in ENDOCRINOLOGY 12.(2021)
