单位：[1]Department of Hepatobiliary Surgery, Mengchao Hepatobiliary Hospital of Fujian Medical University, Xihong Road 312, Fuzhou 350025, Fujian, People’s Republic of China[2]College of Biological Science and Engineering, Fuzhou University, Fuzhou, Fujian, China[3]Department of Hepatobiliary Surgery, The Second Hospital Affiliated to Zhejiang University, Zhejiang, Hangzhou, China[4]Department of Hepatobiliary Surgery, The Southwest Hospital Affiliated to the Army Medical University, Chongqing, China[5]Department of Hepatobiliary Surgery, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, China[6]Department of Hepatobiliary Surgery, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China华中科技大学同济医学院附属同济医院[7]Department of Hepatobiliary Surgery, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing, China临床科室国家中心普外分中心普外三科（肝胆外科）首都医科大学附属北京友谊医院[8]Department of Hepatobiliary Surgery, The West China Hospital of Sichuan University, Chengdu, Sichuan, China[9]Department of Hepatobiliary Surgery, Renji Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China[10]Department of Hepatobiliary Surgery, Xuanwu Hospital Affiliated to Capital Medical University, Beijing, China首都医科大学宣武医院[11]Department of Hepatobiliary Surgery, The Affiliated Hospital of Chuanbei Medical University, Nanchong, Sichuan, China[12]Department of Hepatobiliary Surgery, Tiantan Hospital Affiliated to Capital Medical University, Beijing, China首都医科大学附属天坛医院[13]Department of Hepatobiliary Surgery III, Eastern Hepatobiliary Surgery Hospital, Secondary Military Medical University, Shanghai, China[14]Department of Hepatobiliary Surgery, Zhongda Hospital Southeast University, Nanjing, Jiangsu, China.
BackgroundThe objective of this study was to investigate the survival outcomes of surgical margin width in intrahepatic cholangiocarcinoma (ICC).MethodsBetween November 2011 and August 2017, patients who underwent hepatectomy for ICC were collected from 13 major hepatopancreatobiliary centers in China. The survival outcomes for patients who underwent wide margin hepatectomy (WMH) were compared with those who underwent narrow margin hepatectomy (NMH) using the 1:1 propensity score matching (PSM).ResultsAmong 478 included patients, 195 (40.8%) underwent WMH whereas 283 (59.2%) underwent NMH. PSM yielded 79 matched patients with similar baseline characteristics. Patients underwent WMH had a significant better OS and DFS compared with those underwent NMH (before PSM: median OS 27 vs 17months, P<0.05; median DFS 15 vs 8months, P=0.001, after PSM: median OS 41 vs 22months, p<0.05; median DFS 16 vs 10months, p<0.05). However, subgroup analysis based on the AJCC staging system, WMH could only improve the survival outcomes in AJCC I ICC patients (Stage I: OS, DFS, P<0.05).ConclusionsSurgeons should strive to achieve a wide surgical margin for patients with AJCC I ICC to optimize the long-term outcome.
基金：
Fujian Medical University [2019QH1294]; Fujian provincial health research talent training project [2019-1-85]; Fuzhou Science and Technology Bureau project [2020-WS-92]
第一作者单位：[1]Department of Hepatobiliary Surgery, Mengchao Hepatobiliary Hospital of Fujian Medical University, Xihong Road 312, Fuzhou 350025, Fujian, People’s Republic of China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Hepatobiliary Surgery, Mengchao Hepatobiliary Hospital of Fujian Medical University, Xihong Road 312, Fuzhou 350025, Fujian, People’s Republic of China[2]College of Biological Science and Engineering, Fuzhou University, Fuzhou, Fujian, China
推荐引用方式(GB/T 7714)：
Liu Hongzhi,Lin Lianku,Lin Ziguo,et al.Impact of surgical margin width on long-term outcomes for intrahepatic cholangiocarcinoma: a multicenter study[J].BMC CANCER.2021,21(1):doi:10.1186/s12885-021-08560-7.
APA：
Liu Hongzhi,Lin Lianku,Lin Ziguo,Chen Yifan,Huang Qizhen...&Zeng Yongyi.(2021).Impact of surgical margin width on long-term outcomes for intrahepatic cholangiocarcinoma: a multicenter study.BMC CANCER,21,(1)
MLA：
Liu Hongzhi,et al."Impact of surgical margin width on long-term outcomes for intrahepatic cholangiocarcinoma: a multicenter study".BMC CANCER 21..1(2021)
