单位：[1]Department of Oncology Third Xiangya Hospital Central South University Changsha, Hunan 410013, China[2]Department of Oncological Radiotherapy Hunan Academy of Traditional Chinese Medicine Affiliated Hospital Changsha, Hunan 410006, China[3]Department of General Surgery China-Japan Friendship Hospital Beijing 100029, China[4]Beijing National Laboratory for Molecular Sciences State Key Laboratory of Polymer Physics and Chemistry Institute of Chemistry Chinese Academy of Sciences Beijing 100190, China
Cisplatin has been used as standard regimen for hepatocellular carcinoma (HCC), but its therapeutic efficacy is greatly limited by the drug resistance. Cisplatin alone cannot achieve an ideal therapeutic outcome. Herein, a dual threat hybrid artemisinin platinum (ArtePt) is synthesized to combine chemodynamic therapy (CDT) with chemotherapy. On the one hand, artesunate can react with intracellular ferrous ion to generate reactive oxygen species (ROS) via Fenton reaction for CDT. On the other hand, cisplatin can target DNA for chemotherapy. However, GSH in cancer cells can effectively consume free radicals and detoxify cisplatin simultaneously, which compromised the efficacy of CDT and chemotherapy. Hence, an amphiphilic polymer with an iodine atom in the side chain is designed and encapsulated ArtePt to form NP(ArtePt). This iodine containing polymer NP(ArtePt) can effectively deplete intracellular GSH via an Iodo-Click reaction, thereby enhancing the effect of CDT as well as chemotherapy. Thereafter, a patient-derived xenograft model of hepatic carcinoma (PDXHCC) is established to evaluate the therapeutic effect of NP(ArtePt), and a significant antitumor effect is achieved with NP(ArtePt). Overall, this study provides an effective strategy to combine CDT with chemotherapy to enhance the efficacy of cisplatin via Iodo-Click reaction, opening a new avenue for the cancer treatment.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81872473]; Hunan Province Science and Technology Plan [2017SK2052]; New Xiangya Talent Project of the Third Xiangya hospital of Central South University [20180301]
第一作者单位：[1]Department of Oncology Third Xiangya Hospital Central South University Changsha, Hunan 410013, China
通讯作者：
推荐引用方式(GB/T 7714)：
Jin Qiao,Yan Siqi,Hu Hao,et al.Enhanced Chemodynamic Therapy and Chemotherapy via Delivery of a Dual Threat ArtePt and Iodo-Click Reaction Mediated Glutathione Consumption[J].SMALL METHODS.2021,5(12):doi:10.1002/smtd.202101047.
APA：
Jin, Qiao,Yan, Siqi,Hu, Hao,Jin, Long,Pan, Yuliang...&Cao, Peiguo.(2021).Enhanced Chemodynamic Therapy and Chemotherapy via Delivery of a Dual Threat ArtePt and Iodo-Click Reaction Mediated Glutathione Consumption.SMALL METHODS,5,(12)
MLA：
Jin, Qiao,et al."Enhanced Chemodynamic Therapy and Chemotherapy via Delivery of a Dual Threat ArtePt and Iodo-Click Reaction Mediated Glutathione Consumption".SMALL METHODS 5..12(2021)
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