单位：[1]Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China,[2]National Center for Respiratory Medicine, Beijing, China,[3]Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China,[4]National Clinical Research Center for Respiratory Diseases, Beijing, China,[5]Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China,[6]Department of Respiratory Medicine, Capital Medical University, Beijing, China
Aim: To summarize the incidence of right heart catheter diagnosed chronic thromboembolic pulmonary hypertension (CTEPH) after acute pulmonary embolism (PE) in a meta-analysis. Methods: Cohort studies reporting the incidence of CTEPH after acute PE were identified via search of Medline, Embase, China National Knowledge Infrastructure and WanFang databases. Results: Twenty-two cohort studies with 5,834 acute PE patients were included. Pooled results showed that the overall incidence of CTEPH was 2.82% (95% CI: 2.11-3.53%). Subgroup analyses showed higher incidence of CTEPH in Asians than Europeans (5.08 vs. 1.96%, p = 0.01), in retrospective cohorts than prospective cohorts (4.75 vs. 2.47%, p = 0.02), and in studies with smaller sample size than those with larger sample size (4.57 vs. 1.71%, p < 0.001). Stratified analyses showed previous venous thromboembolic events and unprovoked PE were both significantly associated with increased risk of CTEPH (OR = 2.57 and 2.71, respectively; both p < 0.01). Conclusions: The incidence of CTEPH after acute PE is similar to 3% and the incidence is higher in Asians than Europeans. Efforts should be made for the early diagnosis and treatment of CTEPH in PE patients, particularly for high-risk population.
基金：
Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences (CIFMS) [2018-I2M-1-003]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81970058]; MSD China Holding Co. Ltd.
第一作者单位：[1]Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China,[2]National Center for Respiratory Medicine, Beijing, China,[3]Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China,[4]National Clinical Research Center for Respiratory Diseases, Beijing, China,[5]Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China,
共同第一作者：
通讯作者：
通讯机构：[1]Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China,[2]National Center for Respiratory Medicine, Beijing, China,[3]Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China,[4]National Clinical Research Center for Respiratory Diseases, Beijing, China,[5]Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China,[6]Department of Respiratory Medicine, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Wenyi Pang,Zhu Zhang,Zenghui Wang,et al.Higher Incidence of Chronic Thromboembolic Pulmonary Hypertension After Acute Pulmonary Embolism in Asians Than in Europeans: A Meta-Analysis[J].FRONTIERS in MEDICINE.2021,8:doi:10.3389/fmed.2021.721294.
APA：
Wenyi Pang,Zhu Zhang,Zenghui Wang,Kaiyuan Zhen,Meng Zhang...&Zhenguo Zhai.(2021).Higher Incidence of Chronic Thromboembolic Pulmonary Hypertension After Acute Pulmonary Embolism in Asians Than in Europeans: A Meta-Analysis.FRONTIERS in MEDICINE,8,
MLA：
Wenyi Pang,et al."Higher Incidence of Chronic Thromboembolic Pulmonary Hypertension After Acute Pulmonary Embolism in Asians Than in Europeans: A Meta-Analysis".FRONTIERS in MEDICINE 8.(2021)
