单位：[1]Department of Traditional Chinese Medcine, Beijing Friendship Hospital, Capital Medical University.临床科室中医科中医科首都医科大学附属北京友谊医院[2]Department of pharmacy, Beijing Maternity Hospital, Capital Medical University.[3]College of Traditional Chinese Medicine, Capital Medical University, No.10, Youanmenwai Xitoutiao, Fengtai District, Beijing, China.
Diabetic peripheral neuropathy (DPN) is one of the most common complications of diabetes with limited therapies. Tang Luo Ning (TLN), a traditional Chinese medicine compound, has been proved to be effective in the treatment of DPN in clinical and experimental studies. However, the potential metabolic mechanism of TLN for the treatment of DPN is still unclear. Here the therapeutic effect of TLN on DPN was studied, and HPLC-IT-TOF/MS was used to explore the metabolic changes related to DPN and to explore the mechanism of TLN on DPN induced by high glucose. Furthermore, metabolic pathway analysis was used to explore the metabolic changes induced by DPN and TLN. As a result, TLN could improve the peripheral nerve function of DPN rats, and TLN could reduce the demyelination of the sciatic nerve in DPN rats. Metabolomics analysis showed that 14 potential biomarkers (citrate, creatine, fumarate, glyceric acid, glycine, succinate, etc.) of both DPN and TLN treatment were identified. Pathway analysis showed that the changes in these metabolites were mainly related to the citrate cycle (TCA cycle); glycine, serine, and threonine metabolism; and glyoxylate and dicarboxylate metabolism.
基金：
National Natural Science Foundation of China [81774223, 81473663]
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|4 区医学
小类|4 区生化研究方法4 区生化与分子生物学4 区分析化学4 区药学
最新[2025]版：
大类|4 区医学
小类|4 区生化研究方法4 区生化与分子生物学4 区分析化学4 区药学
JCR分区：
出版当年[2020]版：
Q4BIOCHEMICAL RESEARCH METHODSQ4CHEMISTRY, ANALYTICALQ4BIOCHEMISTRY & MOLECULAR BIOLOGYQ4PHARMACOLOGY & PHARMACY
最新[2023]版：
Q3CHEMISTRY, ANALYTICALQ3PHARMACOLOGY & PHARMACYQ4BIOCHEMICAL RESEARCH METHODSQ4BIOCHEMISTRY & MOLECULAR BIOLOGY
第一作者单位：[1]Department of Traditional Chinese Medcine, Beijing Friendship Hospital, Capital Medical University.
通讯作者：
通讯机构：[3]College of Traditional Chinese Medicine, Capital Medical University, No.10, Youanmenwai Xitoutiao, Fengtai District, Beijing, China.[*1]College of Traditional Chinese Medicine, Capital Medical University, No. 10, Youanmenwai Xitoutiao, Fengtai District, Beijing 100069, China
推荐引用方式(GB/T 7714)：
Li Yangfan,Yao Weijie,Gao Yanbin.Effects of Tang Luo Ning on diabetic peripheral neuropathy in rats revealed by LC-MS metabolomics approach[J].BIOMEDICAL CHROMATOGRAPHY.2022,36(7):doi:10.1002/bmc.5374.
APA：
Li Yangfan,Yao Weijie&Gao Yanbin.(2022).Effects of Tang Luo Ning on diabetic peripheral neuropathy in rats revealed by LC-MS metabolomics approach.BIOMEDICAL CHROMATOGRAPHY,36,(7)
MLA：
Li Yangfan,et al."Effects of Tang Luo Ning on diabetic peripheral neuropathy in rats revealed by LC-MS metabolomics approach".BIOMEDICAL CHROMATOGRAPHY 36..7(2022)
