单位：[1]Centre for Quantum Physics, Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement (MOE), School of Physics, Beijing Institute of Technology, Beijing 100081, China[2]Yangtze Delta Region Academy of Beijing Institute of Technology, Jiaxing 314000, China[3]Department of Rheumatology, China-Japan Friendship Hospital, Beijing 100029, China[4]School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China
A large-size Bi2Se3 tape electrode (BTE) was prepared by peeling off a 2 x 1 x 0.5 cm high-quality single crystal. The feasibility of using the flexible BTE as an efficient bioplatform to load Au nanoparticles and probe DNA for HIV-1 DNA electrochemical sensing was explored. Differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS) show that the resultant biosensor has a wide linear range from 0.1 fM to 1 pM, a low detection limit of 50 aM, excellent selectivity, reproducibility and stability, and is superior to the pM DNA detection level of Pt-Au, graphene-AuNPs hybrid biosensors. This outstanding performance is attributed to the intrinsic surface state of Bi2Se3 topological insulator in facilitating electron transfer. Therefore, BTE electrochemical biosensor platform has great potential in the application for sensitive detection of DNA biomarkers.
基金：
National Natural Science Foundation
of China (Grant Nos. 11734003, 92065109), the National
Key Research and Development Program of China (Grant No.
2020YFA0308800), the Beijing Natural Science Foundation (Grant No.
Z210006), and Beijing Institute of Technology Research Fund Program
for Young Scholars (Grant Nos. 3180012222011, 3180011182122).
第一作者单位：[1]Centre for Quantum Physics, Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement (MOE), School of Physics, Beijing Institute of Technology, Beijing 100081, China[2]Yangtze Delta Region Academy of Beijing Institute of Technology, Jiaxing 314000, China
通讯作者：
通讯机构：[1]Centre for Quantum Physics, Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement (MOE), School of Physics, Beijing Institute of Technology, Beijing 100081, China[2]Yangtze Delta Region Academy of Beijing Institute of Technology, Jiaxing 314000, China
推荐引用方式(GB/T 7714)：
Xiong Xiaolu,Zhu Peng,Li Shanshan,et al.Electrochemical biosensor based on topological insulator Bi2Se3 tape electrode for HIV-1 DNA detection[J].MICROCHIMICA ACTA.2022,189(8):doi:10.1007/s00604-022-05365-8.
APA：
Xiong, Xiaolu,Zhu, Peng,Li, Shanshan,Jiang, Yujiu,Ma, Yurong...&Han, Junfeng.(2022).Electrochemical biosensor based on topological insulator Bi2Se3 tape electrode for HIV-1 DNA detection.MICROCHIMICA ACTA,189,(8)
MLA：
Xiong, Xiaolu,et al."Electrochemical biosensor based on topological insulator Bi2Se3 tape electrode for HIV-1 DNA detection".MICROCHIMICA ACTA 189..8(2022)
