The seeds of Moringa oleifera Lam (MO) in India have various biological properties, such as anti-hyperglycemia, anti-fibrosis, and anti-oxidant. Diabetic nephropathy (DN) is one of the most serious complications in diabetes mellitus. However, the mechanism of renal protection of MO seeds in DN is unclear. In this study, the DN rat model was generated by a single streptozotocin (STZ) intraperitoneal injection, which was used to explore the renal dysfunction effects of MO seeds. Pathological examination of diabetic kidney exhibited a significant change in glomerular and tubular structures. MO seeds treatment in DN rats attenuated these changes dose-dependently. MO seeds could exert anti-inflammatory, anti-fibrosis and anti-oxidative effects by inhibiting the activation of the NF-kappa B and TGF beta 1/Smad2/3 signaling pathways, and activating the Nrf2/HO-1 signaling pathway, finally effectively attenuate renal injury of DN. And 4000 mg/kg MO seeds have the similar level of therapeutic effect as clinical doses of metformin.
基金：
National Natural Science Foun-dation of China [81803769]; Liaoning Provincial Education Department [2020LJC15]
第一作者单位：[2]Shenyang Pharmaceut Univ, Sch Funct Food & Wine, Wenhua Rd 103, Shenyang 110016, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
He Bo-sai,Wang Xiao,Zhang Ying,et al.Anti-oxidant, anti-inflammatory, and anti-fibrotic effects of Moringa oleifera seeds on renal injury diabetic induced by streptozotocin[J].JOURNAL of FUNCTIONAL FOODS.2022,95:doi:10.1016/j.jff.2022.105168.
APA：
He, Bo-sai,Wang, Xiao,Zhang, Ying,Gao, Cheng,Wu, Cheng-kai...&Wang, Jia-hong.(2022).Anti-oxidant, anti-inflammatory, and anti-fibrotic effects of Moringa oleifera seeds on renal injury diabetic induced by streptozotocin.JOURNAL of FUNCTIONAL FOODS,95,
MLA：
He, Bo-sai,et al."Anti-oxidant, anti-inflammatory, and anti-fibrotic effects of Moringa oleifera seeds on renal injury diabetic induced by streptozotocin".JOURNAL of FUNCTIONAL FOODS 95.(2022)
