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Ameliorative effect of acetylshikonin on cigarette smoke-induced lung inflammation in mice

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收录情况： ◇ SCIE

作者：

单位： [1]Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing 100029, China [2]National Clinical Research Center for Respiratory Diseases, Beijing 100029, China [3]Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing 100029, China [4]Department of Emergency, China-Japan Friendship Hospital, Beijing 100029, China

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关键词： Acetylshikonin smoke inhalation COPD inflammation oxidative stress

摘要：

Cigarette smoke exposure is the major cause of chronic obstructive pulmonary disease (COPD). Acetylshikonin was the active principle component of Purple Gromwell that show anti-oxidative and anti-inflammatory effect. However, no data are available to elucidate the protective effect of acetylshikonin on COPD. Acetylshikonin could attenuate smoke-induced lung pathological changes, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-1 beta (IL-1 beta), and monocyte chemoattractant protein 1 (MCP-1) productions, and tissue damages caused by oxidative stress. Furthermore, acetylshikonin was found to enhance the expression of Nrf2 and Nur77-mediated COX-2 in vivo and in vitro.

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出版当年[2019]版：

大类 | 4 区医学

小类 | 4 区应用化学 4 区药物化学 4 区药学 4 区植物科学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区应用化学 4 区药物化学 4 区药学 4 区植物科学

JCR分区：

出版当年[2018]版：

Q3 CHEMISTRY, APPLIED Q3 PLANT SCIENCES Q4 PHARMACOLOGY & PHARMACY Q4 CHEMISTRY, MEDICINAL

最新[2023]版：

Q3 CHEMISTRY, APPLIED Q3 PLANT SCIENCES Q4 CHEMISTRY, MEDICINAL Q4 PHARMACOLOGY & PHARMACY

影响因子： 最新[2023版] 1.3 最新五年平均[2021-2025] 1.5 出版当年[2018版] 1.17 出版当年五年平均[2014-2018] 1.199 出版前一年[2017版] 1.091 出版后一年[2019版] 1.345

第一作者：

第一作者单位： [1]Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing 100029, China [2]National Clinical Research Center for Respiratory Diseases, Beijing 100029, China [3]Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing 100029, China

通讯作者：

通讯机构： [4]Department of Emergency, China-Japan Friendship Hospital, Beijing 100029, China [*1]Department of Emergency, China-Japan Friendship Hospital, Beijing 100029, China

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