单位：[1]Department of Clinical Research and Data Management, Center of Respiratory Medicine, China-Japan Friendship Hospital, National Center for Respiratory Medicine, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, National Clinical Research Center for Respiratory Diseases,Beijing 100029, China[2]Department of Pulmonary and Critical Care Medicine,Center of Respiratory Medicine, China-Japan Friendship Hospital, NationalCenter for Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of MedicalScience, Peking Union Medical College, Beijing 100029, China[3]Departmentof Respiration, Dongzhimen Hospital, Beijing University of Chinese Medicine,Beijing 100027, China[4]Department of Pulmonary and Critical Care Medicine,Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China北京朝阳医院[5]Department of Respiratory and Critical Care Medicine, China-Japan Friendship Hospital, 2 Yinghuayuan E St, Chaoyang District, Beijing 100029, China
Background Recent years, idiopathic pulmonary fibrosis (IPF) is thought to be a disease of alveoli as well as small airways. This study aimed to demonstrate the clinical feature, predictor, and prognosis of small airway dysfunction (SAD) in Chinese patients with IPF. Methods We enrolled 416 patients with IPF who hospitalized in Beijing Chao-Yang Hospital from 2000 to 2014 in this study, and the follow-up ended at December 2016. We collected demographic information, clinical examination results, spirometry results, HRCT results, and blood gas results during the study. Logistic regression analysis was used to identify the predictor for SAD. The COX proportional hazard model was used to analysis the prognosis effect of SAD. Results Among all the participants, 165 (39.66%) patients had SAD. FEV1 (% predicted) and FEV3/FVC were significantly associated with SAD in patients with IPF. IPF patients with lower FEV1 (% predicted, OR 30.04, 95% CI 9.61-93.90) and FEV3/FVC (OR 77.76, 95% CI 15.44-391.63) had increased risk for SAD. Patients with SAD were associated with significantly increased risk of mortality in patients with IPF (HR 1.73, 95% CI 1.02-2.92), as well as in IPF patients without other pulmonary comorbidities (COPD, emphysema, and asthma). Conclusions Spirometry-defined SAD was like 40% in patients with IPF. Lower FEV1 (% predicted) and FEV3/FVC were main predictors for SAD. IPF patients with SAD showed poorer prognosis.
基金：
national key R&D program of China [2016YFC0901101]
第一作者单位：[1]Department of Clinical Research and Data Management, Center of Respiratory Medicine, China-Japan Friendship Hospital, National Center for Respiratory Medicine, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, National Clinical Research Center for Respiratory Diseases,Beijing 100029, China
共同第一作者：
通讯作者：
通讯机构：[2]Department of Pulmonary and Critical Care Medicine,Center of Respiratory Medicine, China-Japan Friendship Hospital, NationalCenter for Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of MedicalScience, Peking Union Medical College, Beijing 100029, China[4]Department of Pulmonary and Critical Care Medicine,Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China[5]Department of Respiratory and Critical Care Medicine, China-Japan Friendship Hospital, 2 Yinghuayuan E St, Chaoyang District, Beijing 100029, China
推荐引用方式(GB/T 7714)：
Xinran Zhang,Bingbing Xie,Chenjun Ban,et al.Small airway dysfunction in Chinese patients with idiopathic pulmonary fibrosis[J].BMC PULMONARY MEDICINE.2022,22(1):doi:10.1186/s12890-022-02089-6.
APA：
Xinran Zhang,Bingbing Xie,Chenjun Ban,Yanhong Ren,Qiao Ye...&Huaping Dai.(2022).Small airway dysfunction in Chinese patients with idiopathic pulmonary fibrosis.BMC PULMONARY MEDICINE,22,(1)
MLA：
Xinran Zhang,et al."Small airway dysfunction in Chinese patients with idiopathic pulmonary fibrosis".BMC PULMONARY MEDICINE 22..1(2022)
