高级检索
当前位置: 首页 > 详情页

Endogenous Stimuli-Responsive Nanoparticles for Cancer Therapy: From Bench to Bedside

文献详情

资源类型:
WOS体系:
Pubmed体系:

收录情况: ◇ SCIE

单位: [1]Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China [2]Oncology Department, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing 100102, China [3]Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory of Acupuncture [4]Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing 100029, China [5]Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Zhejiang 310024, China [6]School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China [7]Clinical Research Center, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai [8]Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna 17165, Sweden [9]Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna 17165, Sweden [10]School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore [11]Department of Microbiology, Tumor, and Cell Biology (MTC), Karolinska Institutet, Stockholm 17177, Sweden
出处:
ISSN:

关键词: Cancer Nanocarrier Tumor microenvironment Targeted therapy Endogenous-stimuli responsive nanoparticles

摘要:
Cancer is complicated to treat because of its high propensity for recurrence and metastasis, and various side effects of conventional cancer treatments. With the development of nanotechnology, biology, material science and pharmacy, nanoparticles emerge as a promising method to load anti-cancer drugs to deal with the downsides of conventional treatments. Among the various class of nanoparticles, endogenous stimuli-responsive nanoparticles exert significant anti-cancer effects by releasing drugs due to the stimulations from pH gradient, redox as well as other enzymes of cancer microenvironment. Extraordinary progress has been achieved as the latest endogenous stimuli-responsive nanoparticles exhibit better therapeutic effects, lower toxicity, and superior biocompatibility, indicating brighter prospects for cancer therapy. However, these stimuli-responsive nanoparticles are still not ready for large-scale clinical application, due to reasons such as the lack of clinical trials and high cost of manufacturing. Here, we consolidate the advancements and limitations of various endogenous stimuli-responsive nanoparticles, as well as critically discuss the prospects of this kind of nanoparticles in tumor treatments.Copyright © 2022 Elsevier Ltd. All rights reserved.

语种:
WOS:
PubmedID:
中科院(CAS)分区:
出版当年[2021]版:
大类 | 2 区 医学
小类 | 2 区 药学
最新[2025]版:
大类 | 2 区 医学
小类 | 1 区 药学
JCR分区:
出版当年[2020]版:
Q1 PHARMACOLOGY & PHARMACY
最新[2023]版:
Q1 PHARMACOLOGY & PHARMACY

影响因子: 最新[2023版] 最新五年平均[2021-2025] 出版当年[2020版] 出版当年五年平均[2016-2020] 出版前一年[2019版] 出版后一年[2021版]

第一作者:
第一作者单位: [1]Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China [2]Oncology Department, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing 100102, China
共同第一作者:
通讯作者:
通讯机构: [10]School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore [11]Department of Microbiology, Tumor, and Cell Biology (MTC), Karolinska Institutet, Stockholm 17177, Sweden [*1]School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.
推荐引用方式(GB/T 7714):
APA:
MLA:

资源点击量:1320 今日访问量:0 总访问量:816 更新日期:2025-04-01 建议使用谷歌、火狐浏览器 常见问题

版权所有:重庆聚合科技有限公司 渝ICP备12007440号-3 地址:重庆市两江新区泰山大道西段8号坤恩国际商务中心16层(401121)