Immune checkpoint inhibitors (ICIs) have changed the status of tumor immunotherapy. ICIs-related adverse events (irAEs) have the high incidence and are difficult to predict and prevent. Researches have suggested that changes of cytokines were associated with irAEs. This study focused on the changes of interleukin-6 (IL-6) and interferon-gamma in patients before and after irAEs and trying to find the biomarkers of irAEs. Collect basic data of patients who were treated with ICIs in China-Japan Friendship Hospital from January 2017 to August 2021 and had irAEs. Make statistics on IL-6 and INF-gamma in the blood before and after irAEs. A total of 10 patients were enrolled, including 7 males and 3 females. According to statistical analysis, the IL-6 concentration level after irAEs was significantly higher than before, and the difference was statistically significant (P = .023); the interferon-gamma concentration level was not changed significantly from before, the difference was not statistically significant (P = .853). The elevation of IL-6 was associated with the occurrence of adverse reactions in ICIs.
基金：
Capital Health Development Research Project
of China (shoufa-2022-2-4065) and the National High Level Hospital Clinical
Research Funding (2022-NHLHCRF-LX-02-0111).
第一作者单位：[1]Beijing Univ Chinese Med, Beijing, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[2]Japan Friendship Hosp, Integrat Oncol Dept, Beijing, Peoples R China[*1]Japan Friendship Hosp, Integrat Oncol Dept, Beijing 100029, Peoples R China
推荐引用方式(GB/T 7714)：
Zhang Xu,Lu Xingyu,Yu Yixuan,et al.Changes of IL-6 And IFN-gamma before and after the adverse events related to immune checkpoint inhibitors: A retrospective study[J].MEDICINE.2022,101(46):doi:10.1097/MD.0000000000031761.
APA：
Zhang, Xu,Lu, Xingyu,Yu, Yixuan,Tan, Kexin&Cui, Huijuan.(2022).Changes of IL-6 And IFN-gamma before and after the adverse events related to immune checkpoint inhibitors: A retrospective study.MEDICINE,101,(46)
MLA：
Zhang, Xu,et al."Changes of IL-6 And IFN-gamma before and after the adverse events related to immune checkpoint inhibitors: A retrospective study".MEDICINE 101..46(2022)
