单位：[1]Department of Urology, Beijing Youan Hospital, Capital Medical University, Beijing, China,[2]Beijing Key Laboratory for HIV/ AIDS Research, Capital Medical University, Beijing, China,[3]Department of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong, China,[4]Translational Medicine Research Center, North Sichuan Medical College, Nanchong, China,[5]Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, China,[6]Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, China临床科室泌尿外科泌尿外科首都医科大学附属北京友谊医院
Objective:& nbsp;To investigate the characteristics and mechanism of the dynamics of HBV infection with the progression of HIV disease and to explore the different responses of T lymphocytes to HBV in HIV patients in different stages of disease.& nbsp;Methods:& nbsp;We compared the rates and characteristics of HBV coinfection between 372 early HIV-infected and 306 chronically HIV-infected men who have sex with men (MSM) in the Beijing Youan Hospital from October 2006 to November 2014. We further analysed IFN-gamma-producing HBV-specific CD8+ T cells in 15 early HIV-infected individuals and 20 chronic HIV-infected individuals with HBV coinfection.& nbsp;Results:& nbsp;Twenty-three HBsAg-positive cases were detected among the 372 early HIV-infected patients of this cohort, and the coinfection rate was 6.18%, while 35 HBsAg-positive cases were detected among the 306 chronically HIV-infected patients, with a coinfection rate of 11.44%. The coinfection rate of the chronically HIV-infected patients was significantly higher than that of the early-infected patients (p=0.0005). The median CD4+ T cell count in the early HIV infection patients was 445 cells/mu L (196-1,030 cells/mu L), which was higher than that in the chronic HIV infection patients [358 cells/mu L (17-783 cells/mu L)] (p < 0.001). The proportion of IFN-gamma-producing CD8+ T cells in early HIV-infected patients was significantly higher than that in chronically HIV-infected patients.& nbsp;Conclusion:& nbsp;The coinfection rate of HBV in HIV patients increases with HIV disease progression, which might be related to the decreased IFN-gamma-producing HBV-specific CD8+ T cell numbers. The closely monitored HBV serum markers from the early stage of HIV infection are warranted.
基金：
National Science and Technology Major Project of the Ministry of Science and Technology of China [2018ZX10302104-002]; Innovation Groups of the National Natural Science Foundation of China [81721002]; National Mega-Projects of Science Research for the 13th Five-Year Plan of China [2018ZX10301407005-001, 2018ZX10302103-001-003]
第一作者单位：[1]Department of Urology, Beijing Youan Hospital, Capital Medical University, Beijing, China,
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推荐引用方式(GB/T 7714)：
Zhu Zhiqiang,Qin Yuanyuan,Liang Qi,et al.Increased HBV Coinfection and Decreased IFN-gamma-Producing HBV-Specific CD8+T Cell Numbers During HIV Disease Progression[J].FRONTIERS in IMMUNOLOGY.2022,13:doi:10.3389/fimmu.2022.861804.
APA：
Zhu Zhiqiang,Qin Yuanyuan,Liang Qi,Xia Wei,Zhang Tong...&Tian Ye.(2022).Increased HBV Coinfection and Decreased IFN-gamma-Producing HBV-Specific CD8+T Cell Numbers During HIV Disease Progression.FRONTIERS in IMMUNOLOGY,13,
MLA：
Zhu Zhiqiang,et al."Increased HBV Coinfection and Decreased IFN-gamma-Producing HBV-Specific CD8+T Cell Numbers During HIV Disease Progression".FRONTIERS in IMMUNOLOGY 13.(2022)
医学