单位：[1]Department of Physiology II, Kanazawa Medical University, Uchinada, Ishikawa, 920- 0293, Japan[2]Department of Colorectal and Hernia Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, 110032, China[3]Department of Hematology, The Fourth Affiliated Hospital of China Medical University, Shenyang, 110032, China[4]Department of Anesthesiology, China-Japan Friendship Hospital, Beijing, 100029, China[5]Department of Infectious Disease, The Sheng Jing Hospital of China Medical University, Shenyang, 110009, China中国医科大学附属盛京医院
We previously reported that sympathetic nerve activity (SNA) to the kidney and the hindlimb increases during anaphylactic hypotension in anaesthetized rats. Based on this evidence, we examined effects of anaphylactic hypotension on SNA to the brown adipose tissue (BAT), and the adrenal gland and kidney in anaesthetized rats. We demonstrated that adrenal and renal SNA, but not BAT-SNA, were stimulated. In addition, the effects of anaphylaxis on neural activities of the hypothalamic and medullary nuclei, which are candidates for relaying efferent SNA to the peripheral organs, were investigated via immunohistochemical staining of c-fos. Anaphylaxis increased c-fos expression in the neurons of the paraventricular nucleus (PVN) of the hypothalamus and in those of the nucleus tractus solitarii (NTS) and rostral ventrolateral medulla (RVLM) of the medulla oblongata; c-fos was expressed in -aminobutyric acid (GABA)-ergic neurons of the NTS and in the catecholaminergic neurons of the RVLM. In addition, c-fos expression in the rostral NTS and mid NTS during anaphylaxis was reduced by sinoaortic baroreceptor denervation; however, increased c-fos expression in the caudal NTS and RVLM or adrenal sympathoexcitation were not affected by sinoaortic baroreceptor denervation. These results indicated that anaphylactic hypotension activates the hypothalamic PVN and the medullary NTS and RVLM independently of the baroreflex pathway. Further, it stimulated efferent SNA to the adrenal gland and kidney to restore blood pressure.
基金：
Kanazawa Medical University [S2013-1]; Nippon Ham Foundation for the Future of Food; Ministry of Education, Culture, Sports, Science and Technology of JapanMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT) [25462839]
第一作者单位：[1]Department of Physiology II, Kanazawa Medical University, Uchinada, Ishikawa, 920- 0293, Japan[*1]Department ofPhysiology II, KanazawaMedical University, Uchinada 920- 0293, Japan.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Physiology II, Kanazawa Medical University, Uchinada, Ishikawa, 920- 0293, Japan[*1]Department ofPhysiology II, KanazawaMedical University, Uchinada 920- 0293, Japan.
推荐引用方式(GB/T 7714)：
Mamoru Tanida,Tao Zhang,Lingling Sun,et al.Anaphylactic hypotension causes renal and adrenal sympathoexcitaion and induces c-fos in the hypothalamus and medulla oblongata[J].EXPERIMENTAL PHYSIOLOGY.2018,103(6):790-806.doi:10.1113/EP086809.
APA：
Mamoru Tanida,Tao Zhang,Lingling Sun,Jie Song,Wei Yang...&Toshishige Shibamoto.(2018).Anaphylactic hypotension causes renal and adrenal sympathoexcitaion and induces c-fos in the hypothalamus and medulla oblongata.EXPERIMENTAL PHYSIOLOGY,103,(6)
MLA：
Mamoru Tanida,et al."Anaphylactic hypotension causes renal and adrenal sympathoexcitaion and induces c-fos in the hypothalamus and medulla oblongata".EXPERIMENTAL PHYSIOLOGY 103..6(2018):790-806
