Objective The objective was to review the factors affecting the feasibility of performing successful laparoscopic colectomy. Data sources The literatures about the risk factors closely related to the ability to perform laparoscopic colectomy on different surgical diseases of the colon cited in this review were obtained from PubMed published in English from 2006 to 2012. Study selection Original articles regarding the risk factors that affect the ability to perform laparoscopic colectomy were selected. Results Obesity, diabetes, inflammatory bowel diseases, advanced age, emergency operation, and pelvic anatomy are all important risk factors that increase the risk of developing serious complications such as hemorrhage, anastomotic leak, and skin and soft tissue infections following laparoscopic colectomy. These factors also increase the likelihood of conversion to an open operation. In this study, we reviewed the recent original articles about the relationship of laparoscopic colectomy with these risk factors. We also describe some strategies that limit the likelihood of these complications and the likelihood of conversion to an open operation. Conclusions Obesity, diabetes, inflammatory bowel diseases, age, emergency operation, and pelvic anatomy are all important risk factors that increase the risk of either serious complications or conversion to open operation with laparoscopic colectomy. Evaluation of these risk factors preoperatively should influence the decision to perform colectomy using laparoscopic techniques.