单位：[1]Department of Neurology, China-Japan Friendship Hospital, Beijing 100029, China[2]Department of Nephrology, Beijing Anzhen Hospital, Beijing 100029, China首都医科大学附属安贞医院[3]Clinical Research Institute, China-Japan Friendship Hospital, Beijing 100029, China
This study aimed to investigate the underlying pathological muscle damage in neuromyelitis optica spectrum disorder (NMOSD) patients without muscular symptoms. We prospectively enrolled 15 patients with aquaporin 4 (AQP4) antibody seropositive NMOSD and 16 patients with non-NMOSD diseases as a control group. Biceps biopsy samples from 18 patients were examined. Six NMOSD patients exhibited inflammatory lesions/edema in lower muscles on muscle MRI. On histopathological examination, NMOSD samples showed significantly decreased IgG-targeting AQP4 expression on sarcolemma compared with non-NMOSD samples in terms of the area of positive staining and integrated optical density. Muscle biopsy can support the differential diagnosis of NMOSD.
第一作者单位：[1]Department of Neurology, China-Japan Friendship Hospital, Beijing 100029, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, China-Japan Friendship Hospital, Beijing 100029, China[*1]Department of Neurology, China-Japan Friendship Hospital, 2 Yinghua, Dongjie, Hepingli, Beijing 100029, China
推荐引用方式(GB/T 7714)：
Zhang Weihe,Dong Mingrui,Dong Hongrui,et al.Reduced sarcolemmal aquaporin 4 expression can support the differential diagnosis of neuromyelitis optica spectrum disorders[J].JOURNAL of NEUROIMMUNOLOGY.2020,339:doi:10.1016/j.jneuroim.2019.577121.
APA：
Zhang, Weihe,Dong, Mingrui,Dong, Hongrui,Wang, Wei,Sun, Weiliang...&Jiao, Jinsong.(2020).Reduced sarcolemmal aquaporin 4 expression can support the differential diagnosis of neuromyelitis optica spectrum disorders.JOURNAL of NEUROIMMUNOLOGY,339,
MLA：
Zhang, Weihe,et al."Reduced sarcolemmal aquaporin 4 expression can support the differential diagnosis of neuromyelitis optica spectrum disorders".JOURNAL of NEUROIMMUNOLOGY 339.(2020)
