单位：[1]Department of Oncology, Beijing Friendship Hospital, Capital Medical University, #95 Yong An Road, Beijing, Xicheng District, China.临床科室肿瘤中心肿瘤内科首都医科大学附属北京友谊医院[2]Yale School of Medicine, New Haven, CT, USA.[3]Department of Cardiology, Chaoyang Hospital, Capital Medical University, Beijing, Chaoyang District, China.北京朝阳医院
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with high mortality, which threats peoples' health. Unfortunately, the pathogenesis of PDAC remains unclear. Recent studies have indicated that long non-coding RNAs (lncRNAs) can regulate the development and progression of malignant tumors through varying mechanisms. LncRNA H19 has a unique expression profile and can act as a sponger of specific miRNAs to regulate the pathogenic process of many diseases, including PDAC and several other types of cancers. Here, we review the research approaches to understanding the regulatory role of H19 and potential mechanisms in the progression of PDAC and other types of cancers and diseases. These studies suggest that H19 may be a novel therapeutic target for PDAC and our findings may open new revenues for scientific researches and development of valuable therapies for these diseases in the future.
基金：
Beijing Municipal Administration of Hospitals'Youth Program [QML20150107]; Capital Health Research and Development of Special Fund [2016-4-1112]; Beijing Key Specialty
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|3 区医学
小类|3 区生化与分子生物学3 区医学：研究与实验4 区细胞生物学
最新[2025]版：
大类|2 区医学
小类|2 区生化与分子生物学2 区细胞生物学2 区医学：研究与实验
JCR分区：
出版当年[2018]版：
Q2BIOCHEMISTRY & MOLECULAR BIOLOGYQ2MEDICINE, RESEARCH & EXPERIMENTALQ3CELL BIOLOGY
最新[2023]版：
Q1BIOCHEMISTRY & MOLECULAR BIOLOGYQ1MEDICINE, RESEARCH & EXPERIMENTALQ2CELL BIOLOGY
第一作者单位：[1]Department of Oncology, Beijing Friendship Hospital, Capital Medical University, #95 Yong An Road, Beijing, Xicheng District, China.[2]Yale School of Medicine, New Haven, CT, USA.
通讯作者：
推荐引用方式(GB/T 7714)：
Wang Jing,Zhao Lei,Shang Kun,et al.Long non-coding RNA H19, a novel therapeutic target for pancreatic cancer[J].MOLECULAR MEDICINE.2020,26(1):doi:10.1186/s10020-020-00156-4.
APA：
Wang, Jing,Zhao, Lei,Shang, Kun,Liu, Fang,Che, Juanjuan...&Cao, Bangwei.(2020).Long non-coding RNA H19, a novel therapeutic target for pancreatic cancer.MOLECULAR MEDICINE,26,(1)
MLA：
Wang, Jing,et al."Long non-coding RNA H19, a novel therapeutic target for pancreatic cancer".MOLECULAR MEDICINE 26..1(2020)
医学