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A novel nomogram to predict all-cause readmission or death risk in Chinese elderly patients with heart failure

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单位: [1]China Japan Friendship Hosp, Dept Cardiol, 2 Yinghua Dongjie, Beijing 100029, Peoples R China [2]Peking Univ, Hosp 3, Res Ctr Clin Epidemiol, Beijing, Peoples R China [3]Hebei Gen Hosp, Dept Cardiol, Shijiazhuang, Hebei, Peoples R China [4]Peking Univ, Peoples Hosp, Dept Cardiovasc Surg, Beijing, Peoples R China [5]Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol & Dev Biol, Beijing, Peoples R China [6]Univ Chinese Acad Sci, Beijing, Peoples R China [7]Peking Univ, Peoples Hosp, Dept Lab Med, Beijing, Peoples R China
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关键词: Heart failure Elderly All-cause readmission Mortality Nomogram Prognostic model

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Aims Elderly patients with heart failure (HF) are associated with frequent all-cause readmission or death. The present study sought to develop an accurate and easy-to-use model to predict all-cause readmission or death risk in Chinese elderly patients with HF. Methods and results This was a prospective cohort study in patients with HF aged 65 or older. Demographic, co-morbidity, laboratory, and medication data were collected. A Cox regression model was used to identify factors for the prediction of readmission or death at 30 days and 1 year. A nomogram was developed with bootstrap validation. Of the included 854 patients, the cumulative all-cause readmission and mortality rates were 10.5% and 11.6% at 30 days and 34.9% and 19.7% at 1 year, respectively. The independent risk factors associated with both 30 day and 1 year readmission or death were older age, stroke, diastolic blood pressure < 60 mmHg, body mass index <= 18.5 kg/m(2), lower estimated glomerular filtration rate, and BNP > 400 pg/mL (all P < 0.05). Anaemia, abnormal neutrophils, and admission without angiotensin-converting enzyme inhibitors/angiotensin receptor blockers were the specific independent risk factors of 30 day all-cause readmission or death (all P < 0.05), whereas serum sodium <= 140 mmol/L and admission without beta-blockers were the specific independent risk factors of 1 year all-cause readmission or death (all P < 0.05). The C-index of the 30 day and 1 year diagnosis prediction model was 0.778 [95% confidence interval (CI) 0.693-0.862] and 0.738 (95% CI 0.640-0.836), respectively. Conclusions We developed accurate and easy-to-use nomograms to predict all-cause readmission or death in Chinese elderly patients with HF. The nomograms will assist in reducing the all-cause readmission and mortality rates.

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出版当年[2019]版:
大类 | 3 区 医学
小类 | 3 区 心脏和心血管系统
最新[2025]版:
大类 | 3 区 医学
小类 | 3 区 心脏和心血管系统
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出版当年[2018]版:
Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
最新[2023]版:
Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

影响因子: 最新[2023版] 最新五年平均[2021-2025] 出版当年[2018版] 出版当年五年平均[2014-2018] 出版前一年[2017版] 出版后一年[2019版]

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第一作者单位: [1]China Japan Friendship Hosp, Dept Cardiol, 2 Yinghua Dongjie, Beijing 100029, Peoples R China
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