CD8 expression in anaplastic large cell lymphoma correlates with noncommon morphologic variants and T-cell antigen expression suggesting biological differences with CD8-negative anaplastic large cell lymphoma
单位：[1]Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA[2]Department of Hematology, Capital Medical University Beijing Friendship Hospital, Beijing, China临床科室血液科血液科首都医科大学附属北京友谊医院[3]Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Anaplastic large cell lymphoma (ALCL) is a T-cell neoplasm characterized by uniformly strong CD30 expression and common absence of T-cell markers. Most ALCL cases express CD4, but a small subset of ALCL cases has been reported to express CD8. Little is known about the clinicopathologic and prognostic features of CD8+ ALCL. In this study, CD8 was assessed in 158 patients with systemic ALCL: CD8 was positive in 13 of 67 (19%) ALK+ and 13 of 91 (14%) ALK-negative neoplasms. In ALK+ ALCL, the CD8+ subgroup more often showed a noncommon morphologic pattern (69% vs 13%, P = .0001) and was more often positive for CD2 (100% vs 45%, P = .001), CD3 (92% vs 24%, P = .0001), and CD7 (100% vs. 39%, P = .002), but less frequently positive for CD25 (50% vs. 100%, P = .02). Patients with ALK+ ALCL and CD8+ neoplasms also had a higher relapse rate (82% vs 48%, P = .05) and more often underwent stem cell transplant (73% vs 36%, P = .04). CD8 expression did not correlate with patient overall survival or progression-free survival regardless of ALK status (all P > 0.05). We conclude that CD8+ ALCL cases appear to be biologically different from the more common CD8- negative ALCL cases. Our data suggest that CD8 positivity in ALK+ ALCL helps to identify a subset of patients more prone to relapse or more in need of stem cell transplant during their clinical course, although there was no impact on survival in this cohort. (C) 2020 Published by Elsevier Inc.
第一作者单位：[1]Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA[2]Department of Hematology, Capital Medical University Beijing Friendship Hospital, Beijing, China
通讯作者：
通讯机构：[1]Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA[*1]Department of Hematopathology, MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 72, Houston, TX, 77030, USA.
推荐引用方式(GB/T 7714)：
Shen Jing,Medeiros L. Jeffrey,Li Shaoying,et al.CD8 expression in anaplastic large cell lymphoma correlates with noncommon morphologic variants and T-cell antigen expression suggesting biological differences with CD8-negative anaplastic large cell lymphoma[J].HUMAN PATHOLOGY.2020,98:1-9.doi:10.1016/j.humpath.2020.01.005.
APA：
Shen, Jing,Medeiros, L. Jeffrey,Li, Shaoying,Wang, Sa A.,Lin, Pei...&Xu, Jie.(2020).CD8 expression in anaplastic large cell lymphoma correlates with noncommon morphologic variants and T-cell antigen expression suggesting biological differences with CD8-negative anaplastic large cell lymphoma.HUMAN PATHOLOGY,98,
MLA：
Shen, Jing,et al."CD8 expression in anaplastic large cell lymphoma correlates with noncommon morphologic variants and T-cell antigen expression suggesting biological differences with CD8-negative anaplastic large cell lymphoma".HUMAN PATHOLOGY 98.(2020):1-9
