单位：[1]Clinical Medicine School of China-Japan friendship, Peking Union Medical College, Beijing, China[2]Department of Nephrology, Beijing Luhe Hospital, Capital Medical University, China[3]Department of Nephrology, China-Japan Friendship Hospital, Beijing, China
Introduction: The aims of this study were to assess the renal expression of angiotensin II type 1 receptor (AT1R), angiotensin II type 2 receptor (AT2R), and MAS receptor in human type 2 diabetic nephropathy (DN). Materials and methods: In total, 115 patients diagnosed with DN by renal biopsy were enrolled in this study. The protein expression levels of the AT1R, AT2R, and MAS receptors were assessed by immunohistochemistry. Results: The protein expression levels of AT1R, AT2R, and MAS receptor in the renal biopsy tissue were correlated with the pathologic classification of DN. Tubulointerstitial AT1R expression in patients of class IIb was significantly stronger than control samples (p < 0.05). Expression of AT2R and MAS receptors were highest with class IIb DN patients. When DN patients were treated with AT1R blocker (ARB), the expression of AT1R was downregulated (p < 0.05), and the MAS receptor was upregulated in tubular interstitial (p < 0.05). Conclusions: Our results directly observed that renal expression levels of AT1R increase during the early stages of DN, ARB reducing AT1R while increasing MAS receptor. Therefore, ARB should be used as soon as possible in patients with DN.
基金：
Beijing Municipal Science and Technology Project [D171100002817003, D171100002817004]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81600547]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7202179]
第一作者单位：[1]Clinical Medicine School of China-Japan friendship, Peking Union Medical College, Beijing, China[2]Department of Nephrology, Beijing Luhe Hospital, Capital Medical University, China
共同第一作者：
通讯作者：
通讯机构：[1]Clinical Medicine School of China-Japan friendship, Peking Union Medical College, Beijing, China[3]Department of Nephrology, China-Japan Friendship Hospital, Beijing, China[*1]Department of Nephrology, China-Japan Friendship Hospital, No 2 Yinghua East Street, Chaoyang district, Beijing 100029, China.
推荐引用方式(GB/T 7714)：
Ma Ye-Ping,Yang Yue,Jiang Shi-Min,et al.Angiotensin II type 1 receptor blockers favorably affect renal angiotensin II and MAS receptor expression in patients with diabetic nephropathy[J].JOURNAL of the RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM.2020,21(2):doi:10.1177/1470320320919607.
APA：
Ma, Ye-Ping,Yang, Yue,Jiang, Shi-Min,Liu, Lin,Zhang, Zheng...&Li, Wen-Ge.(2020).Angiotensin II type 1 receptor blockers favorably affect renal angiotensin II and MAS receptor expression in patients with diabetic nephropathy.JOURNAL of the RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM,21,(2)
MLA：
Ma, Ye-Ping,et al."Angiotensin II type 1 receptor blockers favorably affect renal angiotensin II and MAS receptor expression in patients with diabetic nephropathy".JOURNAL of the RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM 21..2(2020)
