Long non-coding RNAs mortal obligate RNA transcript regulates the proliferation of human periodontal ligament stem cells and affects the recurrence of periodontitis
单位：[1]Department of Stomatology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, PR China临床科室口腔科口腔科首都医科大学附属北京友谊医院[2]Department of Stomatology, The First Hospital of Jilin University, Changchun City, Jilin Province, 130021, PR China[3]Department of Endodontics, School and Hospital of Stomatology, Jilin University, Changchun City, Jilin Province, 130021, PR China[4]Department of Dental Implantology, School and Hospital of Stomatology, Jilin University, Jinlin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Changchun City, Jilin Province, 130021, PR China
Objective: The aim of this study is to investigate the role of long non-coding RNAs (lncRNA), mortal obligate RNA transcript (MORT), in human periodontal ligament stem cells. Design: Periodontal ligament tissues were collected from 48 periodontitis patients underwent tooth extraction and 38 people in similar age and gender distributions who experienced orthodontic treatment. After treatment, periodontitis patients were followed up for 2 years. MORT in periodontal ligament stem cells (PDLSCs) was detected by qRT-PCR. Proliferation of PDLSCs was detected by CCK-8 assay. Results: The proliferation rate of PDLSCs isolated from periodontitis-affected teeth was significantly higher than PDLSCs from healthy teeth. Overexpression of MORT inhibited the proliferation of both types of periodontal ligament stem cells. After treatment, periodontitis patients were followed up for 2 years and patients with high level of MORT expression showed relatively lower recurrence rate comparing to low expression group. Conclusion: MORT is involved in the proliferation of human PDLSCs and affects the recurrence of periodontitis.
基金：
Health and Family Planning Research Subject of Jilin Province, China [2016Q019, 3D5171683431]
第一作者单位：[1]Department of Stomatology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, PR China
共同第一作者：
通讯作者：
通讯机构：[4]Department of Dental Implantology, School and Hospital of Stomatology, Jilin University, Jinlin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Changchun City, Jilin Province, 130021, PR China[*1]Department of Dental Implantology, School and Hospital of Stomatology, Jilin University, Jinlin Provincial Key Laboratory of Tooth Development and Bone Remodeling, No. 1500 Qinghua Road, Changchun City, Jilin Province, 130021, PR China
推荐引用方式(GB/T 7714)：
Wang Yanhua,Sun Yingying,Zheng Peng,et al.Long non-coding RNAs mortal obligate RNA transcript regulates the proliferation of human periodontal ligament stem cells and affects the recurrence of periodontitis[J].ARCHIVES of ORAL BIOLOGY.2019,105:1-4.doi:10.1016/j.archoralbio.2019.04.013.
APA：
Wang, Yanhua,Sun, Yingying,Zheng, Peng,Cai, Chunyu,Jiang, Yu...&Cai, Qing.(2019).Long non-coding RNAs mortal obligate RNA transcript regulates the proliferation of human periodontal ligament stem cells and affects the recurrence of periodontitis.ARCHIVES of ORAL BIOLOGY,105,
MLA：
Wang, Yanhua,et al."Long non-coding RNAs mortal obligate RNA transcript regulates the proliferation of human periodontal ligament stem cells and affects the recurrence of periodontitis".ARCHIVES of ORAL BIOLOGY 105.(2019):1-4
