单位：[1]Department of Gastroenterological Surgery, Laboratory of Surgical Oncology, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People’s Hospital, Beijing, China[2]Clinical Epidemiology and EBM Unit, National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Beijing, China医技科室北京市临床医学研究所国家消化中心（方法学平台）首都医科大学附属北京友谊医院
Aim Anastomotic leakage (AL) is one of the most feared postoperative complications after anterior resection (AR) of rectal cancer. An adequate blood supply at the anastomotic site is regarded as a prerequisite for healing. We hypothesize that the Aortic Calcification Index (ACI) might reflect the severity of atherosclerosis in patients, and thereby be a risk factor for AL. Method AL was investigated retrospectively according to the definition of the International Study Group of Rectal Cancer in 423 rectal cancer patients who underwent anterior rectal resection. The ACI was measured by preoperative abdominal CT scan. The cross-section of the aorta was evenly divided into 12 sectors, the number of calcified sectors was counted as the calcification score of each slice. Lasso logistic regression and multivariate regression analysis were used to identify risk factors for AL. Results The percentage of AL after AR was 7.8% (33/423); the mortality of patients who sustained a leak was 3.0% (1/33). Patients with a high ACI had a significantly higher percentage of AL than patients with low ACI (11.2% vs 5.6%, P = 0.04). Among patients with AL, a higher ACI was associated with greater severity of AL (the ACI of patients with grade A leakage, grade B leakage and grade C leakage was 0.5% +/- 0.2%, 11.5% +/- 9.2% and 24.2% +/- 21.7%, respectively; P = 0.008). After risk adjustment, multivariate regression analysis showed that a higher ACI was an independent risk factor for AL (OR 2.391, P = 0.04). Conclusion A high ACI might be an important prognostic factor for AL after AR for rectal cancer. Confirmatory studies are required.
第一作者单位：[1]Department of Gastroenterological Surgery, Laboratory of Surgical Oncology, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People’s Hospital, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Gastroenterological Surgery, Laboratory of Surgical Oncology, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People’s Hospital, Beijing, China[*1]Department of Gastroenterological Surgery, Laboratory of Surgical Oncology, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People’s Hospital, Beijing 100044, China
推荐引用方式(GB/T 7714)：
Shen Z.,An Y.,Shi Y.,et al.The Aortic Calcification Index is a risk factor associated with anastomotic leakage after anterior resection of rectal cancer[J].COLORECTAL DISEASE.2019,21(12):1397-1404.doi:10.1111/codi.14795.
APA：
Shen, Z.,An, Y.,Shi, Y.,Yin, M.,Xie, Q....&Ye, Y..(2019).The Aortic Calcification Index is a risk factor associated with anastomotic leakage after anterior resection of rectal cancer.COLORECTAL DISEASE,21,(12)
MLA：
Shen, Z.,et al."The Aortic Calcification Index is a risk factor associated with anastomotic leakage after anterior resection of rectal cancer".COLORECTAL DISEASE 21..12(2019):1397-1404
