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MicroRNA-34a inhibits bladder cancer cell migration and invasion, and upregulates PTEN expression

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收录情况： ◇ SCIE

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单位： [1]Department of Urology, China‑Japan Friendship Hospital, Beijing 100029, P.R. China [2]Department of Urology, Peking University China‑Japan Friendship School of Clinical Medicine, Beijing 100029, P.R. China

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关键词： bladder cancer migration invasion microRNA-34a phosphatase and tensin homolog

摘要：

MicroRNA-34a (miR-34a) serves as a tumor suppressor in a number of different types of cancer. The present study was performed to investigate the involvement of miR-34a in bladder cancer. In the present study, miR-34a was downregulated in patients with bladder cancer compared with the healthy controls in bladder biopsies and plasma. Downregulation of miR-34a distinguished between patients with bladder cancer and the healthy controls. miR-34a expression was associated with tumor metastasis; however, not with tumor size. Transfection of miR-34a mimics upregulated the expression of phosphatase and tensin homolog (PTEN) in bladder cancer cells, and decreased cell migration and invasion. miR-34a may inhibit bladder cancer cell migration and invasion by upregulating PTEN. miR-34a may additionally serve as a potential therapeutic target for bladder cancer.

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出版当年[2018]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

JCR分区：

出版当年[2017]版：

Q4 ONCOLOGY

最新[2023]版：

Q3 ONCOLOGY

影响因子： 最新[2023版] 2.5 最新五年平均[2021-2025] 2.4 出版当年[2017版] 1.664 出版当年五年平均[2013-2017] 1.654 出版前一年[2016版] 1.39 出版后一年[2018版] 1.871

第一作者：

第一作者单位： [1]Department of Urology, China‑Japan Friendship Hospital, Beijing 100029, P.R. China

通讯作者：

通讯机构： [1]Department of Urology, China‑Japan Friendship Hospital, Beijing 100029, P.R. China [*1]Department of Urology, China‑Japan Friendship Hospital, 2 Ying Hua Road, Chao Yang, Beijing 100029, P.R. China

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