Objective: To investigate the clinical effect of thoracoscopic radical resection of lung cancer in the treatment of early non-small cell lung cancer. Methods: Data were collected from 97 patients with early non-small cell lung cancer admitted to our hospital between March 2018 and March 2019. The patients were divided into control group (n=48) and research group (n=49) according to the digital random method. Routine thoracotomy and thoracoscopic radical resection of lung cancer were used respectively. The clinical therapeutic effects of the two groups were compared. Fruit. Results: The operation time of the study group was longer than that of the control group. The intraoperative bleeding volume, thoracic drainage volume, hospitalization time and dosage of analgesics after operation were all less than those of the control group (p < 0.05); the levels of inflammatory factors in the study group were significantly lower than those of the control group (p < 0.05). The incidence of complications was 6.12% (3/49) in the study group and 20.83% (10/48) in the control group. There was significant difference between the two groups (p < 0.05). CONCLUSION: Thoracoscopic radical resection of lung cancer for early non-small cell lung cancer is effective, the recovery of patients is faster, the incidence of complications is reduced, and the biochemical indicators are significantly decreased after operation, which is worthy of clinical promotion.